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OSCAR - osteoclast associated Ig-like receptor Gene

Also Known as PIGR3; PIgR-3

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 126014

About OSCAR

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,094,668-54,100,803 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 224 orthologues and 25 paralogues. Biased expression in lung (RPKM 7.4), bone marrow (RPKM 7.3) and 12 other tissues.

Summary

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

OSCAR Products (6)

mRNA	Protein	Name
NM_001282349.3	NP_001269278.1	osteoclast-associated immunoglobulin-like receptor isoform 6 precursor
NM_001282350.3	NP_001269279.1	osteoclast-associated immunoglobulin-like receptor isoform 7 precursor
NM_130771.6	NP_570127.3	osteoclast-associated immunoglobulin-like receptor isoform 3 precursor
NM_133168.6	NP_573398.2	osteoclast-associated immunoglobulin-like receptor isoform 5 precursor
NM_133169.6	NP_573399.2	osteoclast-associated immunoglobulin-like receptor isoform 4 precursor
NM_206818.4	NP_996554.2	osteoclast-associated immunoglobulin-like receptor isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	参考文献	由来
enables collagen receptor activity	IDA IDA: Inferred from direct assay	21841309	GOA
enables collagen receptor activity	IMP IMP: Inferred from mutant phenotype	21841309	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
acts upstream of or within osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	21841309	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OSCAR Protein Structure

Ig_2

0
100
200
286 a.a.

Protein Preferred Names	Protein Names
osteoclast-associated immunoglobulin-like receptor	osteoclast associated receptor OSCAR-S1

Recombinant OSCAR Proteins

製品番号	製品名	アクセッション番号	純度
HY-P78011	OSCAR Protein, Human (HEK293, Fc)	Q8IYS5-2 (D19-N229)	≥ 95%, as determined by Bis-Tris PAGE.

Diseases	Alias
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS09847	OSCAR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19466	Oscar Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25959	Oscar Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

阻害性抗体 (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-P992285	Anti-OSCAR Antibody		/	Unkown