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IL17RE - interleukin 17 receptor E Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 132014

About IL17RE

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:9,902,093-9,916,402 (from NCBI)

This gene has 11 transcripts (splice variants), 180 orthologues and 4 paralogues. Broad expression in duodenum (RPKM 10.6), skin (RPKM 9.9) and 17 other tissues.

Summary

This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to Bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]

IL17RE Products (4)

mRNA	Protein	Name
NM_001193380.2	NP_001180309.1	interleukin-17 receptor E isoform 6 precursor
NM_153480.2	NP_705613.1	interleukin-17 receptor E isoform 1 precursor
NM_153481.2	NP_705614.1	interleukin-17 receptor E isoform 2
NM_153483.2	NP_705616.2	interleukin-17 receptor E isoform 5

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	21993848	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL17RE Protein Structure

IL17_R_N

SEFIR

0
200
400
600
667 a.a.

Protein Preferred Names	Protein Names
interleukin-17 receptor E	IL-17 receptor E

IL17RE Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	IL17RE	Q8NFR9	IL17RA	Homo sapiens	Q96F46	Anti Tag CoIP	21993848

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL17RE Proteins

製品番号	製品名	アクセッション番号	純度
HY-P72576	IL-17RE Protein, Human (HEK293, Fc)	Q8NFR9-1 (T155-H454)	≥ 95%, as determined by reducing SDS-PAGE.

関連疾患

Diseases	Alias
Cutaneous Candidiasis	Candidiasis, Cutaneous
Seborrheic Infantile Dermatitis	Cradle Cap Infantile Seborrhoeic Dermatitis Seborrhoea Capitis Seborrhoeic Dermatitis Of Scalp Seborrhoeic Eczema Of Scalp Complement 5 Dysfunction Generalized Seborrheic Dermatitis Of Infants Infantile Seborrheic Dermatitis Pityriasis Capitis Seborrhea Capitis Seborrhea Sicca Dandruff Complement Component 5 Deficiency Seborrheic Dermatitis Seborrheic Dermatitis Of Scalp Scurfiness Of Scalp Seborrheic Dermatitis Of Infancy Infantile Seborrhoeic Eczema Neonatal Seborrhoeic Dermatitis Infantile Seborrhoeic Dermatitis Of The Scalp
Chronic Mucocutaneous Candidiasis	Candidiasis, Chronic Mucocutaneous Cmc Candidiasis Chronic Mucocutaneous

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-P5963	Lib2-1	Inhibitor	99.63%	Unkown
HY-RS06706	IL17RE Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19064	Il17re Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25554	Il17re Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Felis catus	IL17RE	VGNC	VGNC:97464
Mus musculus	IL17RE	MGD	MGI:1889371
Macaca mulatta	IL17RE	VGNC	VGNC:73623
Canis familiaris	IL17RE	VGNC	VGNC:41950
Rattus norvegicus	IL17RE	RGD	RGD:735148
Bos taurus	IL17RE	VGNC	VGNC:30125
Others	IL17RE	NCBI