Skil - SKI-like Gene

Also Known as sno; Skir; SnoN

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 20482

Summary

This gene encodes a member of a small family of proteins that play a key role in the response of cells to extracellular growth signals. The encoded protein regulates members of the transforming growth factor beta signaling pathway. It is highly expressed in certain Cancer cells, where it may have both tumor-suppressing and tumor-promoting roles. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]

Skil Products (6)

mRNA Protein Name
NM_001039090.3 NP_001034179.1 ski-like protein isoform b
NM_001271772.2 NP_001258701.1 ski-like protein isoform c
NM_001398558.1 NP_001385487.1 ski-like protein isoform a
NM_001398559.1 NP_001385488.1 ski-like protein isoform b
NM_001398560.1 NP_001385489.1 ski-like protein isoform b
NM_011386.4 NP_035516.2 ski-like protein isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables chromatin binding IDA
IDA: Inferred from direct assay
15657445 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12522145 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within blastocyst formation IMP
IMP: Inferred from mutant phenotype
10811619 MGI
acts upstream of cell differentiation IDA
IDA: Inferred from direct assay
17215516 MGI
acts upstream of extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: Inferred from mutant phenotype
10811619 MGI
acts upstream of intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
10811619 MGI
acts upstream of or within lens fiber cell differentiation IDA
IDA: Inferred from direct assay
17215516 MGI
acts upstream of or within lymphocyte homeostasis IMP
IMP: Inferred from mutant phenotype
10811619 MGI
acts upstream of or within negative regulation of cell differentiation IDA
IDA: Inferred from direct assay
17215516 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10811619 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
18212064 MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: Inferred from mutant phenotype
10811619 MGI
acts upstream of or within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
10811619 MGI
acts upstream of or within regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
10811619 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IGI
IGI: Inferred from genetic interaction
18212064 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
located in nucleus IDA
IDA: Inferred from direct assay
18212064 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ski-like protein

  • ski-related oncogene

  • ski/sno related

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS12970 SKIL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Skil NCBI NCBI:6498