Plk5 - polo like kinase 5 Gene

Also Known as 6330514A18Rik

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 216166

About Plk5

Chromosome 10: 80,192,293-80,201,323 forward strand.GRCm39:CM001003.3

This gene has 4 transcripts (splice variants), 98 orthologues and 4 paralogues. Biased expression in cerebellum adult (RPKM 19.2), cortex adult (RPKM 4.7) and 6 other tissues.

Summary

Predicted to enable ATP binding activity; metal ion binding activity; and protein kinase activity. Involved in several processes, including defense response to tumor cell; positive regulation of neuron projection development; and regulation of G1/S transition of mitotic cell cycle. Located in nucleolus. Is expressed in several structures, including central nervous system; eye; and ovary. Orthologous to human PLK5 (polo like kinase 5 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]

Plk5 Products (2)

mRNA Protein Name
NM_183152.4 NP_898975.2 inactive serine/threonine-protein kinase PLK5 isoform 1
NM_001347124.1 NP_001334053.1 inactive serine/threonine-protein kinase PLK5 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
NOT enables kinase activity IDA
IDA: Inferred from direct assay
21245385 MGI
Biological Process GO Annotation Evidence 参考文献 由来
involved in DNA damage response IDA
IDA: Inferred from direct assay
20100802 MGI
involved in defense response to tumor cell IDA
IDA: Inferred from direct assay
21245385 MGI
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
21245385 MGI
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
20100802 MGI
involved in positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
21245385 MGI
involved in regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
20100802 MGI
involved in regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
21245385 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
located in nucleolus IDA
IDA: Inferred from direct assay
20100802 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Plk5 Protein Structure

STKc_PLK

STKc_PLK: cd14099 (24 - 278)

POLO_box_1

POLO_box_1: cd13118 (409 - 496)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 595 a.a.
Protein Preferred Names Protein Names

inactive serine/threonine-protein kinase PLK5

  • PLK-5

  • serine/threonine-protein kinase PLK5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS10723 PLK5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10724 Plk5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10725 Plk5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Plk5 NCBI NCBI:126520