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Tp53 - tumor protein p53 Gene

Also Known as p53; Trp53

生物種: Rattus norvegicus

遺伝子タイプ: protein coding

遺伝子ID: 24842

About Tp53

Primary_assembly 10: 54,300,048-54,311,524 forward strand.mRatBN7.2:CM026983.1

This gene has 8 transcripts (splice variants), 251 orthologues, 2 paralogues and is associated with 253 phenotypes. Biased expression in Spleen (RPKM 12.5), Thymus (RPKM 11.3) and 9 other tissues.

Summary

This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, Apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it is believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Alternatively spliced transcript variants have been found for this gene, but the biological validity of the variants has not been determined. p53 pseudogenes have been found on chromosomes 9 and 18. [provided by RefSeq, Jul 2008]

Tp53 Products (1)

mRNA	Protein	Name
NM_030989.3	NP_112251.2	cellular tumor antigen p53

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables MDM2/MDM4 family protein binding	IPI IPI: Inferred from physical interaction	23941874	RGD
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	10329733	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8389468	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15632413	RGD
enables transcription coregulator binding	IPI IPI: Inferred from physical interaction	21792911	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	27013579	RGD
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	16330492	RGD

Biological Process GO Annotation	Evidence	参考文献	由来
involved in apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	17998337	RGD
involved in cellular response to heat	IEP IEP: Inferred from expression pattern	11295070	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	17289031	RGD
involved in cellular response to polyamine macromolecule	IEP IEP: Inferred from expression pattern	11502571	RGD
involved in cellular response to reactive oxygen species	IMP IMP: Inferred from mutant phenotype	24817286	RGD
involved in cellular response to triglyceride	IEP IEP: Inferred from expression pattern	27013579	RGD
involved in negative regulation of DNA biosynthetic process	IMP IMP: Inferred from mutant phenotype	11502571	RGD
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8389468	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	28834365	RGD
acts upstream of negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	30514107	RGD
involved in negative regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	17659301	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16688778	RGD
involved in positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	18026139	RGD
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	23164821	RGD
involved in positive regulation of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	27031958	RGD
involved in positive regulation of leukocyte migration	IMP IMP: Inferred from mutant phenotype	18317410	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11278372	RGD
acts upstream of regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	30514107	RGD
involved in regulation of intracellular pH	IMP IMP: Inferred from mutant phenotype	16688778	RGD
involved in response to UV	IEP IEP: Inferred from expression pattern	17724205	RGD
involved in response to UV-B	IEP IEP: Inferred from expression pattern	22559303	RGD
involved in response to X-ray	IEP IEP: Inferred from expression pattern	17699727	RGD
involved in response to X-ray	IMP IMP: Inferred from mutant phenotype	28834365	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	17542038	RGD
involved in response to caffeine	IEP IEP: Inferred from expression pattern	16544096	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	17651018	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	20961644	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	18337831	RGD
involved in response to metal ion	IEP IEP: Inferred from expression pattern	17466256	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18093815	RGD
involved in response to oxidative stress	IEP IEP: Inferred from expression pattern	17600529	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	17962954	RGD
involved in response to vitamin B3	IEP IEP: Inferred from expression pattern	17516866	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18336558	RGD
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	28834365	RGD

Cellular Component GO Annotation	Evidence	参考文献	由来
located in PML body	IDA IDA: Inferred from direct assay	17289031	RGD
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	10329733	RGD
located in chromatin	IDA IDA: Inferred from direct assay	15632413	RGD
located in nucleus	IDA IDA: Inferred from direct assay	17571083	RGD
part of transcription regulator complex	IDA IDA: Inferred from direct assay	15632413	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tp53 Protein Structure

P53_TAD

P53

P53_tetramer

0
100
200
300
391 a.a.

Protein Preferred Names	Protein Names
cellular tumor antigen p53	transformation related protein 53 tumor protein p53 (Li-Fraumeni syndrome) tumor suppressor p53

Recombinant Tp53 Proteins

製品番号	製品名	アクセッション番号	純度
HY-P71703	p53 Protein, Rat (His)	P10361 (M1-D391)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-A0169A	Methyl aminolevulinate hydrochloride	Activator	98.98%	Unkown
HY-A0169	Methyl aminolevulinate		/	Unkown
HY-A0169AR	Methyl aminolevulinate hydrochloride (Standard)	Activator	/	Unkown

Clinical Phase

Bioactive Molecules (10)

製品番号	製品名	製品効果	純度	Phase
HY-15676	Idasanutlin		99.93%	Phase 3
HY-19980G	Eprenetapopt (GMP)		/	Phase 3
HY-156633	Rezatapopt	p53 Activator	99.78%	Phase 2
HY-P10925	Zolucatetide	Inhibitor	99.31%	Phase 2
HY-P4210	Sulanemadlin	Inhibitor	99.49%	Phase 2
HY-16271	Kevetrin hydrochloride		98.0%	Phase 2
HY-171499	Cenersen	Inhibitor	95.07%	Phase 2
HY-16270	Kevetrin		/	Phase 2
HY-176083	ASTX295		99.81%	Phase 1
HY-124036	DS-7423	Inhibitor	99.83%	Phase 1

Pre-clinical Phase

Bioactive Molecules (49)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-10029	Nutlin-3a		99.13%	Unkown
HY-19980	Eprenetapopt		99.52%	Yes
HY-P1925A	GO-203 TFA		98.39%	Unkown
HY-15898	Y-320		99.03%	Unkown
HY-19980A	PRIMA-1		98.0%	Unkown
HY-158039	YCH2823		99.87%	Unkown
HY-148837	GT19630		98.85%	Unkown
HY-148409	MMRi62		99.59%	Unkown
HY-114231	Exaluren		98.0%	Unkown
HY-D0892	NSP-DMAE-NHS		99.48%	Unkown
HY-W181530	NCT02		98.14%	Unkown
HY-17493	MI-773		96.29%	Unkown
HY-107835	Flumethrin		99.29%	Unkown
HY-179560	PMV6-PEG4-BI2536	Inhibitor	98.47%	Unkown
HY-RS14912	TP53 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N1022	11-Hydroxytephrosin	Inhibitor	≥98.0%	Unkown
HY-RS14915	TP53BP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14922	TP53RK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-10029A	(Rac)-Nutlin-3		98.18%	Unkown
HY-W274807	TM-2-51		/	Unkown
HY-100765	BI-0252		/	Unkown
HY-107835R	Flumethrin (Standard)		/	Unkown
HY-107835S	Flumethrin-d5		/	Unkown
HY-150620	BI-0282	Inhibitor	/	Unkown
HY-164828	Rezatapopt analog-1		/	Unkown
HY-17493A	MI-773 TFA		98.91%	Unkown
HY-175000	L14-8		/	Unkown
HY-178224	Morindone		/	Unkown
HY-180331	NVP-CFC218	Inhibitor	/	Unkown
HY-180371	NF-115	Inducer	/	Unkown
HY-183547	WEE1/PKMYT1-IN-4	Inhibitor	/	Unkown
HY-184116	A2AR/EGFR-IN-1		/	Unkown
HY-184244	CAS-010	Inhibitor	/	Unkown
HY-186013	CML-07-119	Inducer	/	Unkown
HY-P11089	TP53 neoepitope	Substrate	/	Unkown
HY-RS14913	Tp53 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14914	TP53AIP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14916	TP53BP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14917	TP53I11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14918	TP53I13 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14919	TP53I3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14920	TP53INP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14921	TP53INP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15102	Trp53 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-164544	USP7-055	Inhibitor	/	Unkown
HY-174511	Human TP53 mRNA		/	Unkown
HY-183877	YO-2		/	Unkown
HY-RS26028	Tp53i3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28596	Tp53inp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Homo sapiens	Tp53	NCBI	NCBI:7157