Rezatapopt analog-1
Rezatapopt analog-1 (PC14586 analog-1) (1919) is a Rezatapopt (HY-156633) analog. Rezatapopt binds to a pocket created by the TP53 Y220C mutation. Rezatapopt restores p53 tumor suppressor functions by stabilization of the p53 protein structure.
For research use only. We do not sell to patients.
- CAS No.: 2636846-37-0
- Formula: C27H28F4N4O3
- Molecular Weight:532.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NUGC-3 | IC50 |
0.99 μM
Compound: 24
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Cytotoxicity against human NUGC-3 cells harboring TP53 Y220C mutant assessed as reduction in cell viability incubated for 5 days by MTT assay
Cytotoxicity against human NUGC-3 cells harboring TP53 Y220C mutant assessed as reduction in cell viability incubated for 5 days by MTT assay
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[PMID: 39811143] |
Chemical Information
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CAS No. 2636846-37-0
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Molecular Weight 532.53
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Formula C27H28F4N4O3
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SMILES
FC(F)(F)CN1C2=CC=CC(N[C@H]3[C@H](CN(CC3)C)F)=C2C=C1C#CCNC4=C(C=C(C=C4)C(O)=O)OC
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Synonyms
PC14586 analog-1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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