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Cxcr2 - C-X-C motif chemokine receptor 2 Gene

Also Known as Il8rb; Cmkar2

生物種: Rattus norvegicus

遺伝子タイプ: protein coding

遺伝子ID: 29385

About Cxcr2

Primary_assembly 9: 75,729,115-75,739,425 forward strand.mRatBN7.2:CM026982.1

This gene has 1 transcript (splice variant), 244 orthologues, 24 paralogues and is associated with 45 phenotypes. Biased expression in Spleen (RPKM 23.5), Lung (RPKM 14.1) and 4 other tissues.

Summary

Predicted to enable chemokine binding activity and Chemokine Receptor activity. Involved in several processes, including neutrophil chemotaxis; positive regulation of neutrophil chemotaxis; and regulation of apoptotic process. Predicted to be located in several cellular components, including cell surface; mast cell granule; and mitotic spindle. Predicted to be active in external side of plasma membrane. Used to study colitis; demyelinating disease; and nephritis. Biomarker of periapical periodontitis. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; acute pyelonephritis; end stage renal disease; and urinary bladder Cancer. Orthologous to human CXCR2 (C-X-C motif Chemokine Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Cxcr2 Products (1)

mRNA	Protein	Name
NM_017183.2	NP_058879.1	C-X-C chemokine receptor type 2

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	参考文献	由来
involved in acute inflammatory response to antigenic stimulus	IMP IMP: Inferred from mutant phenotype	15516486	RGD
involved in metanephric tubule morphogenesis	IMP IMP: Inferred from mutant phenotype	17634442	RGD
involved in midbrain development	IEP IEP: Inferred from expression pattern	18436867	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17634442	RGD
involved in negative regulation of neutrophil apoptotic process	IMP IMP: Inferred from mutant phenotype	22312020	RGD
involved in neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	10975996	RGD
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	18832730	RGD
involved in positive regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	22562555	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	10975996	RGD
involved in positive regulation of leukocyte chemotaxis	IMP IMP: Inferred from mutant phenotype	17717298	RGD
involved in positive regulation of neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	23947621	RGD
involved in positive regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	19255141	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cxcr2 Protein Structure

7tmA_CXCR1_2

0
100
200
300
359 a.a.

Protein Preferred Names	Protein Names
C-X-C chemokine receptor type 2	CXC-R2 CXCR-2 GRO/MGSA receptor IL-8R B chemokine (C-X-C motif) receptor 2 chemokine (C-X-C) receptor 2 high affinity interleukin-8 receptor B interleukin 8 receptor, beta

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (11)

製品番号	製品名	製品効果	純度	Phase
HY-15251	Reparixin	Inhibitor	99.99%	Phase 3
HY-15252	Reparixin L-lysine salt	Inhibitor	99.87%	Phase 3
HY-19519A	Ladarixin sodium	Antagonist	99.84%	Phase 3
HY-10198	Navarixin	Antagonist	99.33%	Phase 2
HY-13848	Rugocrixan		99.54%	Phase 2
HY-19855	AZD-5069	Antagonist	99.91%	Phase 2
HY-119339	SX-682	Inhibitor	99.64%	Phase 2
HY-50688	SB-265610	Antagonist	99.03%	Phase 2
HY-19768	Danirixin	Antagonist	98.19%	Phase 2
HY-18263C	Elubrixin tosylate	Antagonist	98.14%	Phase 2
HY-18263A	Elubrixin	Antagonist	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (26)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-16711	SB225002	Antagonist	99.90%	Unkown
HY-120427	Cosalane	Antagonist	99.78%	Unkown
HY-101407	Nicotinamide N-oxide	Antagonist	99.85%	Unkown
HY-121983	CAY10594	Modulator	98.64%	Unkown
HY-P4846	Ac-Pro-Gly-Pro-OH	Agonist	99.49%	Unkown
HY-12927	SX-517	Antagonist	99.90%	Unkown
HY-10011	SCH 563705	Antagonist	99.86%	Unkown
HY-101022	CXCR2-IN-1	Inhibitor	99.54%	Unkown
HY-165428	SCH-900875	Inhibitor	98.16%	Unkown
HY-120878	CXCR2-IN-2	Antagonist	99.52%	Unkown
HY-15462	SRT3109	Antagonist	99.68%	Unkown
HY-119259	AZD8309	Antagonist	99.98%	Unkown
HY-147392	CXCR2 antagonist 8	Antagonist	98.38%	Unkown
HY-181654	Snail IN-1	Inhibitor	98.27%	Unkown
HY-13021	SRT3190	Antagonist	99.77%	Unkown
HY-101407R	Nicotinamide N-oxide (Standard)	Antagonist	99.03%	Unkown
HY-181681	CXCR2 antagonist 10	Antagonist	/	Unkown
HY-179387	CXCR2-IN-3	Inhibitor	/	Unkown
HY-110268	NVP CXCR2 20	Antagonist	/	Unkown
HY-144784	CXCR2 antagonist 7	Antagonist	/	Unkown
HY-144780	CXCR2 antagonist 4	Antagonist	/	Unkown
HY-124056	AZ10397767	Antagonist	/	Unkown
HY-144781	CXCR2 antagonist 5	Antagonist	/	Unkown
HY-117823	VUF11418	Agonist	/	Unkown
HY-144783	CXCR2 antagonist 6	Antagonist	/	Unkown
HY-N2573	Corydalmine	Inhibitor	99.74%	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Homo sapiens	Cxcr2	NCBI	NCBI:3579
Mus musculus	Cxcr2	NCBI	NCBI:12765