Cxcr2 - chemokine (C-X-C motif) receptor 2 Gene

Also Known as CD128; IL8RA; Il8rb; CDw128; Cmkar2; Gpcr16; IL-8Rh; IL-8rb; mIL-8RH

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12765

About Cxcr2

Chromosome 1: 74,193,148-74,200,405 forward strand.GRCm39:CM000994.3

This gene has 2 transcripts (splice variants), 244 orthologues, 25 paralogues and is associated with 127 phenotypes. Biased expression in placenta adult (RPKM 4.1), spleen adult (RPKM 3.8) and 8 other tissues.

Summary

Enables Chemokine Receptor activity. Acts upstream of or within negative regulation of apoptotic process. Predicted to be located in several cellular components, including cell surface; mast cell granule; and mitotic spindle. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; epithelium; and heart. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; acute pyelonephritis; end stage renal disease; and urinary bladder Cancer. Orthologous to human CXCR2 (C-X-C motif Chemokine Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Cxcr2 Products (1)

mRNA Protein Name
NM_009909.3 NP_034039.1 C-X-C chemokine receptor type 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables chemokine receptor activity IDA
IDA: Inferred from direct assay
16618742 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14764687 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16618742 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cxcr2 Protein Structure

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (47 - 323)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (47 - 74)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (81 - 106)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (117 - 147)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (158 - 180)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (206 - 234)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (242 - 272)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (291 - 316)

  • 0
  • 100
  • 200
  • 300
  • 359 a.a.
Protein Preferred Names Protein Names

C-X-C chemokine receptor type 2

  • CXC-R2

  • CXCR-2

  • GRO/MGSA receptor

  • IL-8 receptor alpha chain

  • IL-8R B

  • chemokine (C-X-C) receptor 2

  • high affinity interleukin-8 receptor B

  • interleukin 8 receptor, beta

  • interleukin-8 receptor type B

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-15251 Reparixin Inhibitor 99.99% Phase 3
HY-19519A Ladarixin sodium Antagonist 99.84% Phase 3
HY-10198 Navarixin Antagonist 99.33% Phase 2
HY-13848 Rugocrixan 99.54% Phase 2
HY-19855 AZD-5069 Antagonist 99.91% Phase 2
HY-119339 SX-682 Inhibitor 99.64% Phase 2
HY-50688 SB-265610 Antagonist 99.03% Phase 2
HY-19768 Danirixin Antagonist 98.19% Phase 2
HY-15462 SRT3109 Antagonist 99.68% Phase 1

Pre-clinical Phase

Bioactive Molecules (28)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16711 SB225002 Antagonist 99.90% Unkown
HY-15252 Reparixin L-lysine salt Inhibitor 99.87% Yes
HY-120427 Cosalane Antagonist 99.50% Unkown
HY-101407 Nicotinamide N-oxide Antagonist 99.85% Unkown
HY-121983 CAY10594 Modulator 98.64% Unkown
HY-P4846 Ac-Pro-Gly-Pro-OH Agonist 99.49% Unkown
HY-12927 SX-517 Antagonist 99.90% Unkown
HY-18263C Elubrixin tosylate Antagonist 98.14% Unkown
HY-10011 SCH 563705 Antagonist 99.86% Unkown
HY-101022 CXCR2-IN-1 Inhibitor 99.54% Unkown
HY-165428 SCH-900875 Inhibitor 98.16% Unkown
HY-120878 CXCR2-IN-2 Antagonist 99.52% Unkown
HY-119259 AZD8309 Antagonist 99.98% Unkown
HY-147392 CXCR2 antagonist 8 Antagonist 98.38% Unkown
HY-181654 Snail IN-1 Inhibitor 98.27% Unkown
HY-18263A Elubrixin Antagonist / Unkown
HY-13021 SRT3190 Antagonist 99.84% Unkown
HY-101407R Nicotinamide N-oxide (Standard) Antagonist 99.03% Unkown
HY-181681 CXCR2 antagonist 10 Antagonist / Unkown
HY-179387 CXCR2-IN-3 Inhibitor / Unkown
HY-110268 NVP CXCR2 20 Antagonist / Unkown
HY-144784 CXCR2 antagonist 7 Antagonist / Unkown
HY-144780 CXCR2 antagonist 4 Antagonist / Unkown
HY-124056 AZ10397767 Antagonist / Unkown
HY-144781 CXCR2 antagonist 5 Antagonist / Unkown
HY-117823 VUF11418 Agonist / Unkown
HY-144783 CXCR2 antagonist 6 Antagonist / Unkown
HY-N2573 Corydalmine Inhibitor 99.74% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cxcr2 NCBI NCBI:3579