2. Gene
  3. Cxcr2 - chemokine (C-X-C motif) receptor 2 Gene

Cxcr2 - chemokine (C-X-C motif) receptor 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CD128; IL8RA; Il8rb; CDw128; Cmkar2; Gpcr16; IL-8Rh; IL-8rb; mIL-8RH

Gene ID: 12765 | Gene type: protein coding

About Cxcr2

Chromosome 1: 74,193,148-74,200,405 forward strand.GRCm39:CM000994.3

This gene has 2 transcripts (splice variants), 244 orthologues, 25 paralogues and is associated with 127 phenotypes. Biased expression in placenta adult (RPKM 4.1), spleen adult (RPKM 3.8) and 8 other tissues.

Summary

Enables Chemokine Receptor activity. Acts upstream of or within negative regulation of apoptotic process. Predicted to be located in several cellular components, including cell surface; mast cell granule; and mitotic spindle. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; epithelium; and heart. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; acute pyelonephritis; end stage renal disease; and urinary bladder Cancer. Orthologous to human CXCR2 (C-X-C motif Chemokine Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Cxcr2 Products(1)

mRNA Protein Name
NM_009909.3 NP_034039.1 C-X-C chemokine receptor type 2

Cxcr2 Protein Structure

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (47 - 323)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (47 - 74)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (81 - 106)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (117 - 147)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (158 - 180)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (206 - 234)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (242 - 272)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (291 - 316)

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  • 359 a.a.
Protein Preferred Names Protein Names

C-X-C chemokine receptor type 2

CXC-R2

CXCR-2

GRO/MGSA receptor

IL-8 receptor alpha chain

IL-8R B

chemokine (C-X-C) receptor 2

high affinity interleukin-8 receptor B

interleukin 8 receptor, beta

interleukin-8 receptor type B

Related Agents

Clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-15251 Reparixin Inhibitor 99.95% Phase 3
HY-15252 Reparixin L-lysine salt Inhibitor 99.66% Phase 3
HY-19519A Ladarixin sodium Antagonist 99.15% Phase 3
HY-10198 Navarixin Antagonist 98.90% Phase 2
HY-13848 AZD8797 98.73% Phase 2
HY-19855 AZD-5069 Antagonist 99.76% Phase 2
HY-119339 SX-682 Inhibitor 99.67% Phase 2
HY-19768 Danirixin Antagonist 98.45% Phase 2
HY-18263C Elubrixin tosylate Antagonist 99.78% Phase 2
Pre-clinical Phase
Bioactive Molecules (18)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16711 SB225002 Antagonist 99.87% Unkown
HY-50688 SB-265610 Antagonist ≥99.0% Unkown
HY-101407 Nicotinamide N-oxide Antagonist 99.85% Unkown
HY-101022 CXCR2-IN-1 Inhibitor 99.47% Unkown
HY-147392 CXCR2 antagonist 8 Antagonist 99.24% Unkown
HY-120878 CXCR2-IN-2 Antagonist 99.52% Unkown
HY-13021 SRT3190 Antagonist 99.77% Unkown
HY-119259 AZD8309 Antagonist 99.98% Unkown
HY-10011 SCH 563705 Antagonist 98.20% Unkown
HY-15462 SRT3109 Antagonist 99.82% Unkown
HY-P4846 Ac-Pro-Gly-Pro-OH Agonist / Unkown
HY-144784 CXCR2 antagonist 7 Antagonist / Unkown
HY-101407R Nicotinamide N-oxide (Standard) Antagonist / Unkown
HY-124056 AZ10397767 Antagonist / Unkown
HY-N2573 Corydalmine Inhibitor / Unkown
HY-144781 CXCR2 antagonist 5 Antagonist / Unkown
HY-144780 CXCR2 antagonist 4 Antagonist / Unkown
HY-144783 CXCR2 antagonist 6 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cxcr2 NCBI NCBI:3579