H1-2 - H1.2 linker histone, cluster member Gene
Also Known as H1C; H1.2; H1F2; H1s-1; HIST1H1C
生物種: Homo sapiens
About H1-2
This gene has 1 transcript (splice variant), 81 orthologues and 9 paralogues.
Summary
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
H1-2 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_005319.4 | NP_005310.1 | histone H1.2 |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables chromatin DNA binding |
IDA
IDA: Inferred from direct assay
|
15911621 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
22720776 | GOA |
| Cellular Component GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| located in euchromatin |
IDA
IDA: Inferred from direct assay
|
15911621 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
21383955 | GOA |
H1-2 Protein Structure
Linker_histone: linker histone H1 and H5 family (38 - 109)
- 0
- 100
- 200
- 213 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
histone H1.2 |
|
H1-2 Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Intra
|
H1-2 | P16403 | H2BC21 | Homo sapiens | Q16778 | 30021884 | |
|
Intra
|
H1-2 | P16403 | H2AC21 | Homo sapiens | Q8IUE6 | 30021884 | |
|
Intra
|
H1-2 | P16403 | H2AC21 | Homo sapiens | Q8IUE6 | 33961781 | |
|
Intra
|
H1-2 | P16403 | DDX21 | Homo sapiens | Q9NR30 | 33961781 | |
|
Intra
|
H1-2 | P16403 | FTSJ3 | Homo sapiens | Q8IY81 | 33961781 | |
|
Intra
|
H1-2 | P16403 | BAZ1B | Homo sapiens | Q9UIG0 | 33961781 |
H1-2 抗体
| 製品番号 | 製品名 | アプリケーション | 反応性 |
|---|---|---|---|
| HY-P80158 | Histone H1.2 Antibody (YA383) | WB, IHC-P, ICC/IF, ChIP, IF-Tissue | Human, Mouse, Rat |
関連疾患
| Diseases | Alias | |
|---|---|---|
| Supranuclear Palsy, Progressive, 1 |
|
|
| Pick Disease Of Brain |
|
|
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Macaca mulatta | H1-2 | VGNC | VGNC:109667 |
| Rattus norvegicus | H1-2 | RGD | RGD:1587893 |
| Bos taurus | H1-2 | VGNC | VGNC:83558 |
| Mus musculus | H1-2 | MGD | MGI:1931526 |
| Others | H1-2 | NCBI |