SPATA6 - spermatogenesis associated 6 Gene

Also Known as HASH; SRF1; SRF-1

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 54558

About SPATA6

Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:48,261,389-48,472,204 (from NCBI)

This gene has 11 transcripts (splice variants), 143 orthologues and 1 paralogue. Broad expression in testis (RPKM 10.6), thyroid (RPKM 2.4) and 19 other tissues.

Summary

Predicted to enable Myosin light chain binding activity. Predicted to be involved in motile cilium assembly and spermatogenesis. Predicted to be located in extracellular region. Predicted to be active in sperm connecting piece. [provided by Alliance of Genome Resources, Apr 2022]

SPATA6 Products (3)

mRNA Protein Name
NM_001286238.2 NP_001273167.1 spermatogenesis-associated protein 6 isoform 2
NM_001286239.2 NP_001273168.1 spermatogenesis-associated protein 6 isoform 3
NM_019073.4 NP_061946.1 spermatogenesis-associated protein 6 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPATA6 Protein Structure

SPATA6

SPATA6: Spermatogenesis-assoc protein 6 (11 - 149)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 488 a.a.
Protein Preferred Names Protein Names

spermatogenesis-associated protein 6

  • spermatogenesis-related factor-1

SPATA6 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
SPATA6 Q9NWH7 DDB2 Homo sapiens Q92466
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Spermatogenic Failure 16

  • SPGF16

  • Acephalic Spermatozoa Syndrome

  • Spermatozoa, Acephalic
Male Infertility Due To Acephalic Spermatozoa

  • Acephalic Spermatozoa Syndrome
Myopathy, Areflexia, Respiratory Distress, And Dysphagia, Early-Onset

  • EMARDD

  • Myopathy, Areflexia, Respiratory Distress, And Dysphagia, Early-Onset, Mild Variant

  • Early-Onset Myopathy-Areflexia-Respiratory Distress-Dysphagia Syndrome

  • Early-Onset Myopathy, Areflexia, Respiratory Distress And Dysphagia

  • Myopathy, Early-Onset, Areflexia, Respiratory Distress, And Dysphagia
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS13643 SPATA6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta SPATA6 VGNC VGNC:77953
Felis catus SPATA6 VGNC VGNC:65617
Rattus norvegicus SPATA6 RGD RGD:628657
Bos taurus SPATA6 VGNC VGNC:35189
Canis familiaris SPATA6 VGNC VGNC:46717
Mus musculus SPATA6 MGD MGI:1915196
Others SPATA6 NCBI