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BRF2 - BRF2 RNA polymerase III transcription initiation factor subunit Gene

Also Known as BRFU; TFIIIB50

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 55290

About BRF2

Cytogenetic location: 8p11.23 Genomic coordinates (GRCh38): 8:37,843,268-37,849,861 (from NCBI)

This gene has 4 transcripts (splice variants), 192 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 46.9), prostate (RPKM 42.0) and 24 other tissues.

Summary

This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein. [provided by RefSeq, Jul 2008]

BRF2 Products (1)

mRNA	Protein	Name
NM_018310.4	NP_060780.2	transcription factor IIIB 50 kDa subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables RNA polymerase III type 3 promoter sequence-specific DNA binding	IDA IDA: Inferred from direct assay	26638071	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	26638071	GOA
involved in regulation of transcription by RNA polymerase III	IMP IMP: Inferred from mutant phenotype	26638071	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
part of transcription factor TFIIIB complex	IMP IMP: Inferred from mutant phenotype	26638071	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRF2 Protein Structure

TF_Zn_Ribbon

0
100
200
300
400
419 a.a.

Protein Preferred Names	Protein Names
transcription factor IIIB 50 kDa subunit	B-related factor 2

BRF2 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	BRF2	Q9HAW0	JUP	Homo sapiens	P14923	Anti Tag CoIP	33961781
Intra	BRF2	Q9HAW0	JUP	Homo sapiens	P14923	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Diseases	Alias
Cone-Rod Dystrophy 9	CORD9 Dystrophy, Cone-Rod, Type 9 Retinitis Pigmentosa 9
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS16042	ZFP36L2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01617	BRF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20661	Zfp36l2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	BRF2	RGD	RGD:1308817
Felis catus	BRF2	VGNC	VGNC:60173
Macaca mulatta	BRF2	VGNC	VGNC:70335
Mus musculus	BRF2	MGD	MGI:1913903
Bos taurus	BRF2	VGNC	VGNC:26563
Canis familiaris	BRF2	VGNC	VGNC:38524
Others	BRF2	NCBI