BRF2 - BRF2 RNA polymerase III transcription initiation factor subunit Gene

Also Known as BRFU; TFIIIB50

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55290

About BRF2

Cytogenetic location: 8p11.23 Genomic coordinates (GRCh38): 8:37,843,268-37,849,861 (from NCBI)

This gene has 4 transcripts (splice variants), 192 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 46.9), prostate (RPKM 42.0) and 24 other tissues.

Summary

This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein. [provided by RefSeq, Jul 2008]

BRF2 Products (1)

mRNA Protein Name
NM_018310.4 NP_060780.2 transcription factor IIIB 50 kDa subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase III type 3 promoter sequence-specific DNA binding IDA
IDA: Inferred from direct assay
26638071 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to oxidative stress IMP
IMP: Inferred from mutant phenotype
26638071 GOA
involved in regulation of transcription by RNA polymerase III IMP
IMP: Inferred from mutant phenotype
26638071 GOA
Cellular Component GO Annotation Evidence References Source
part of transcription factor TFIIIB complex IMP
IMP: Inferred from mutant phenotype
26638071 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRF2 Protein Structure

TF_Zn_Ribbon

TF_Zn_Ribbon: TFIIB zinc-binding (6 - 37)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 419 a.a.
Protein Preferred Names Protein Names

transcription factor IIIB 50 kDa subunit

  • B-related factor 2

BRF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BRF2 Q9HAW0 JUP Homo sapiens P14923
Anti Tag CoIP
33961781
Intra
BRF2 Q9HAW0 JUP Homo sapiens P14923
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cone-Rod Dystrophy 9

  • CORD9

  • Dystrophy, Cone-Rod, Type 9

  • Retinitis Pigmentosa 9
Cone-Rod Dystrophy 2

  • Cone-Rod Dystrophy

  • CORD2

  • Cone-Rod Retinal Dystrophy

  • Rcrd2

  • Cone-Rod Retinal Dystrophy 2

  • Crd2

  • Cord

  • Crd

  • Retinal Cone-Rod Dystrophy

  • Cone-Rod Retinal Dystrophy-2

  • Retinal Cone-Rod Dystrophy 2

  • Tapetoretinal Degeneration

  • Cone-Rod Degeneration

  • Cone Rod Dystrophy

  • Dystrophy, Cone-Rod

  • Dystrophy, Cone-Rod, Type 2

  • Retinitis Pigmentosa

  • Retinitis Pigmentosa 2

  • Progressive Cone-Rod Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16042 ZFP36L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01617 BRF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20661 Zfp36l2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus BRF2 RGD RGD:1308817
Felis catus BRF2 VGNC VGNC:60173
Macaca mulatta BRF2 VGNC VGNC:70335
Mus musculus BRF2 MGD MGI:1913903
Bos taurus BRF2 VGNC VGNC:26563
Canis familiaris BRF2 VGNC VGNC:38524
Others BRF2 NCBI