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SLC39A10 - solute carrier family 39 member 10 Gene

Also Known as ZIP10; LZT-Hs2

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 57181

About SLC39A10

Cytogenetic location: 2q32.3 Genomic coordinates (GRCh38): 2:195,613,029-195,737,700 (from NCBI)

This gene has 9 transcripts (splice variants), 185 orthologues and 6 paralogues. Broad expression in thyroid (RPKM 12.9), brain (RPKM 12.5) and 21 other tissues.

Summary

Zinc is an essential cofactor for hundreds of Enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]

SLC39A10 Products (2)

mRNA	Protein	Name
NM_001127257.2	NP_001120729.1	zinc transporter ZIP10 precursor
NM_020342.3	NP_065075.1	zinc transporter ZIP10 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	27274087	GOA
enables zinc ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	27274087	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	27274087	GOA
involved in zinc ion transmembrane transport	IDA IDA: Inferred from direct assay	27274087	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in apical plasma membrane	IDA IDA: Inferred from direct assay	30520657	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	27274087	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC39A10 Protein Structure

Zip

0
200
400
600
831 a.a.

Protein Preferred Names	Protein Names
zinc transporter ZIP10	ZIP-10

関連疾患

Diseases	Alias
Acrodermatitis Enteropathica, Zinc-Deficiency Type	Acrodermatitis Enteropathica AEZ Enteropathica Brandt Syndrome Ae Acrodermatitis Enteropathica Zinc Deficiency Type Danbolt-Cross Syndrome Acrodermatitis Enteropathica, Zinc Deficiency Type Inherited Zinc Deficiency Acrodermatitis Enteropathica, Zinc Deficiency Danbolt-Closs Syndrome Primary Zinc Malabsorption Syndrome
Ehlers-Danlos Syndrome, Spondylodysplastic Type, 3	Spondylocheirodysplasia, Ehlers-Danlos Syndrome-Like Scd-Eds EDSSPD3 Ehlers-Danlos Syndrome Spondylodysplastic Type 3 Ehlers-Danlos Syndrome, Spondylocheirodysplastic Type Slc39a13-Related Spondylodysplastic Ehlers-Danlos Syndrome Slc39a13-Related Speds Slc39a13-Related Spondylodysplastic Eds Spondylocheirodysplastic Ehlers-Danlos Syndrome Speds-Slc39a13 Ehlers-Danlos Syndrome-Like Spondylocheirodysplasia Ehlers-Danlos Syndrome, Spondylodysplastic, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS13229	SLC39A10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Felis catus	SLC39A10	VGNC	VGNC:65354
Bos taurus	SLC39A10	VGNC	VGNC:34858
Macaca mulatta	SLC39A10	VGNC	VGNC:77540
Mus musculus	SLC39A10	MGD	MGI:1914515
Rattus norvegicus	SLC39A10	RGD	RGD:1307321
Canis familiaris	SLC39A10	VGNC	VGNC:57394
Others	SLC39A10	NCBI