EBF4 - EBF family member 4 Gene

Also Known as COE4; OE-4; O/E-4

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 57593

About EBF4

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:2,692,780-2,760,108 (from NCBI)

This gene has 7 transcripts (splice variants), 200 orthologues and 3 paralogues. Broad expression in prostate (RPKM 9.6), endometrium (RPKM 8.9) and 24 other tissues.

Summary

EBF4 belongs to the conserved Olf/EBF family of helix-loop-helix transcription factors, members of which play important roles in neural development and B-cell maturation (Wang et al., 2002 [PubMed 12139918]).[supplied by OMIM, Mar 2008]

EBF4 Products (3)

mRNA Protein Name
NM_001110514.1 NP_001103984.1 transcription factor COE4 isoform 1
NM_001395167.1 NP_001382096.1 transcription factor COE4 isoform 2
NM_001395168.1 NP_001382097.1 transcription factor COE4 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
35939714 GOA
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
35939714 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
35939714 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
35939714 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
35939714 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
35939714 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in chromatin IDA
IDA: Inferred from direct assay
35939714 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EBF4 Protein Structure

TIG

TIG: IPT/TIG domain (256 - 327)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 602 a.a.
Protein Preferred Names Protein Names

transcription factor COE4

  • early B cell factor 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS04127 EBF4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Canis familiaris EBF4 VGNC VGNC:40177
Rattus norvegicus EBF4 RGD RGD:1588215
Felis catus EBF4 VGNC VGNC:80090
Macaca mulatta EBF4 VGNC VGNC:71932
Mus musculus EBF4 MGD MGI:2385972
Bos taurus EBF4 VGNC VGNC:28298
Others EBF4 NCBI