SH2D4A - SH2 domain containing 4A Gene

Also Known as SH2A; PPP1R38

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 63898

About SH2D4A

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:19,313,693-19,396,218 (from NCBI)

This gene has 6 transcripts (splice variants), 229 orthologues and 4 paralogues. Ubiquitous expression in ovary (RPKM 11.6), stomach (RPKM 9.2) and 22 other tissues.

Summary

Enables Phosphatase binding activity. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

SH2D4A Products (5)

mRNA Protein Name
NM_001174159.2 NP_001167630.1 SH2 domain-containing protein 4A isoform a
NM_001174160.2 NP_001167631.1 SH2 domain-containing protein 4A isoform b
NM_001363110.2 NP_001350039.1 SH2 domain-containing protein 4A isoform c
NM_001363111.2 NP_001350040.1 SH2 domain-containing protein 4A isoform c
NM_022071.4 NP_071354.2 SH2 domain-containing protein 4A isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables phosphatase binding IDA
IDA: Inferred from direct assay
19389623 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SH2D4A Protein Structure

SH2

SH2: SH2 domain (347 - 423)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 454 a.a.
Protein Preferred Names Protein Names

SH2 domain-containing protein 4A

  • protein SH(2)A

SH2D4A Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
SH2D4A Q9H788 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
Intra
SH2D4A Q9H788 NECAB2 Homo sapiens Q7Z6G3-2
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 NECAB2 Homo sapiens Q7Z6G3-2
Y2H Array
32296183
Intra
SH2D4A Q9H788 NECAB2 Homo sapiens Q7Z6G3-2
Validated Y2H
25416956
Intra
SH2D4A Q9H788 SH3GL1 Homo sapiens Q6FGM0
Y2H Array
25416956
Intra
SH2D4A Q9H788 NUTM1 Homo sapiens Q86Y26
Y2H Prey Pooling
25416956
Intra
SH2D4A Q9H788 NUTM1 Homo sapiens Q86Y26
Y2H Array
25416956
Intra
SH2D4A Q9H788 CADPS Homo sapiens A2RRN7
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 CADPS Homo sapiens A2RRN7
Y2H Array
32296183
Intra
SH2D4A Q9H788 ZNF774 Homo sapiens Q6NX45
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 ZNF774 Homo sapiens Q6NX45
Y2H Array
32296183
Intra
SH2D4A Q9H788 MAGEA6 Homo sapiens P43360
Y2H Prey Pooling
25416956
Intra
SH2D4A Q9H788 MAGEA6 Homo sapiens P43360
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 MAGEA6 Homo sapiens P43360
Y2H Array
32296183
Intra
SH2D4A Q9H788 PSTPIP1 Homo sapiens O43586
Validated Y2H
25416956
Intra
SH2D4A Q9H788 PSTPIP1 Homo sapiens O43586
Y2H Array
25416956
Intra
SH2D4A Q9H788 HOOK2 Homo sapiens Q96ED9-2
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 HOOK2 Homo sapiens Q96ED9-2
Y2H Array
32296183
Intra
SH2D4A Q9H788 GRAMD4 Homo sapiens Q6IC98
Y2H Array
32296183
Intra
SH2D4A Q9H788 GRAMD4 Homo sapiens Q6IC98
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 PDE4DIP Homo sapiens Q5VU43
Y2H Prey Pooling
25416956
Intra
SH2D4A Q9H788 PDE4DIP Homo sapiens Q5VU43
Validated Y2H
25416956
Intra
SH2D4A Q9H788 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra
SH2D4A Q9H788 TFIP11 Homo sapiens Q9UBB9
Y2H Array
31515488
Intra
SH2D4A Q9H788 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra
SH2D4A Q9H788 TRIML2 Homo sapiens Q8N7C3
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 TRIML2 Homo sapiens Q8N7C3
Y2H Array
32296183
Intra
SH2D4A Q9H788 CDR2L Homo sapiens Q86X02
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 CDR2L Homo sapiens Q86X02
Y2H Array
32296183
Intra
SH2D4A Q9H788 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
SH2D4A Q9H788 CDR2 Homo sapiens Q01850
Y2H Array
32296183
Intra
SH2D4A Q9H788 CDR2 Homo sapiens Q01850
Validated Y2H
25416956
Intra
SH2D4A Q9H788 CDR2 Homo sapiens Q01850
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 FCHSD2 Homo sapiens O94868-3
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 FCHSD2 Homo sapiens O94868-3
Y2H Array
32296183
Intra
SH2D4A Q9H788 FCHO1 Homo sapiens A0A0C3SFZ9
Y2H Array
32296183
Intra
SH2D4A Q9H788 FCHO1 Homo sapiens A0A0C3SFZ9
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 CASK Homo sapiens O14936-4
Y2H Array
32296183
Intra
SH2D4A Q9H788 CASK Homo sapiens O14936-4
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 TACC1 Homo sapiens O75410-7
Y2H Array
32296183
Intra
SH2D4A Q9H788 TACC1 Homo sapiens O75410-7
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra
SH2D4A Q9H788 WWOX Homo sapiens Q9NZC7-5
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
Intra
SH2D4A Q9H788 WWOX Homo sapiens Q9NZC7-5
Y2H Array
32296183
Intra
SH2D4A Q9H788 CASK Homo sapiens O14936
Y2H Array
29892012
Intra
SH2D4A Q9H788 CASK Homo sapiens O14936
Y2H Prey Pooling
25416956
Intra
SH2D4A Q9H788 DBNL Homo sapiens Q9UJU6-2
Validated Y2H
32296183
Intra
SH2D4A Q9H788 DBNL Homo sapiens Q9UJU6-2
Y2H Array
32296183
Intra
SH2D4A Q9H788 DBNL Homo sapiens Q9UJU6-2
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 MBD3L1 Homo sapiens Q8WWY6
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 MBD3L1 Homo sapiens Q8WWY6
Y2H Array
32296183
Intra
SH2D4A Q9H788 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
SH2D4A Q9H788 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 SKAP1 Homo sapiens Q86WV1
Y2H Prey Pooling
25416956
Intra
SH2D4A Q9H788 SKAP1 Homo sapiens Q86WV1
Validated Y2H
25416956
Intra
SH2D4A Q9H788 CCDC172 Homo sapiens P0C7W6
Y2H Prey Pooling
25416956
Intra
SH2D4A Q9H788 CCDC172 Homo sapiens P0C7W6
Y2H Array
25416956
Intra
SH2D4A Q9H788 HMBOX1 Homo sapiens Q6NT76
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 HMBOX1 Homo sapiens Q6NT76
Y2H Array
32296183
Intra
SH2D4A Q9H788 HMBOX1 Homo sapiens Q6NT76
Y2H Prey Pooling
25416956
Intra
SH2D4A Q9H788 VPS52 Homo sapiens Q8N1B4
Y2H Array
25416956
Intra
SH2D4A Q9H788 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
25416956
Intra
SH2D4A Q9H788 PRKAR1B Homo sapiens P31321
Y2H Array
32296183
Intra
SH2D4A Q9H788 PRKAR1B Homo sapiens P31321
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 PNMA1 Homo sapiens Q8ND90
Y2H Array
32296183
Intra
SH2D4A Q9H788 CCDC88B Homo sapiens A6NC98
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 CCDC88B Homo sapiens A6NC98
Y2H Array
32296183
Intra
SH2D4A Q9H788 PPP1CB Homo sapiens P62140
Validated Y2H
25416956
Intra
SH2D4A Q9H788 PPP1CB Homo sapiens P62140
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 PPP1CB Homo sapiens P62140
Y2H Prey Pooling
25416956
Intra
SH2D4A Q9H788 PPP1CB Homo sapiens P62140
Y2H Array
25416956
Intra
SH2D4A Q9H788 PPP1CB Homo sapiens P62140
Y2H Array
32296183
Intra
SH2D4A Q9H788 PPP1CB Homo sapiens P62140
Anti Tag CoIP
33961781
Intra
SH2D4A Q9H788 PPP1CB Homo sapiens P62140
Anti Tag CoIP
28514442
Intra
SH2D4A Q9H788 PPP1CA Homo sapiens P62136
Anti Tag CoIP
28514442
Intra
SH2D4A Q9H788 PPP1CA Homo sapiens P62136
Far-WB
19389623
Intra
SH2D4A Q9H788 PPP1CA Homo sapiens P62136
Anti Tag CoIP
33961781
Intra
SH2D4A Q9H788 STAM2 Homo sapiens O75886
Validated Y2H
25416956
Intra
SH2D4A Q9H788 ALAS1 Homo sapiens P13196
Y2H Array
25416956
Intra
SH2D4A Q9H788 ALAS1 Homo sapiens P13196
Y2H Prey Pooling
25416956
Intra
SH2D4A Q9H788 GRB2 Homo sapiens P62993
Y2H Pooling
20936779
Intra
SH2D4A Q9H788 GRB2 Homo sapiens P62993
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 GRB2 Homo sapiens P62993
Y2H Array
32296183
Intra
SH2D4A Q9H788 SPAG5 Homo sapiens Q96R06
Validated Y2H
25416956
Intra
SH2D4A Q9H788 BLOC1S2 Homo sapiens Q6QNY1
Y2H Array
32296183
Intra
SH2D4A Q9H788 BLOC1S2 Homo sapiens Q6QNY1
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 GPRASP2 Homo sapiens Q96D09
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 GPRASP2 Homo sapiens Q96D09
Y2H Array
32296183
Intra
SH2D4A Q9H788 FSD2 Homo sapiens A1L4K1
Y2H Array
32296183
Intra
SH2D4A Q9H788 FSD2 Homo sapiens A1L4K1
Y2H Prey Pooling
25416956
Intra
SH2D4A Q9H788 FSD2 Homo sapiens A1L4K1
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
SH2D4A Q9H788 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
SH2D4A Q9H788 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra
SH2D4A Q9H788 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra
SH2D4A Q9H788 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra
SH2D4A Q9H788 YPEL2 Homo sapiens Q96QA6
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 YPEL2 Homo sapiens Q96QA6
Y2H Array
32296183
Intra
SH2D4A Q9H788 SH3GL1 Homo sapiens Q99961
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 SH3GL1 Homo sapiens Q99961
Y2H Array
19060904
Intra
SH2D4A Q9H788 SH3GL1 Homo sapiens Q99961
Y2H Pooling
19060904
Intra
SH2D4A Q9H788 SH3GL1 Homo sapiens Q99961
Y2H Array
32296183
Intra
SH2D4A Q9H788 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
SH2D4A Q9H788 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra
SH2D4A Q9H788 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra
SH2D4A Q9H788 NINL Homo sapiens Q9Y2I6
Y2H Array
25416956
Intra
SH2D4A Q9H788 NINL Homo sapiens Q9Y2I6
Y2H Prey Pooling
25416956
Intra
SH2D4A Q9H788 RINT1 Homo sapiens Q6NUQ1
Validated Y2H
25416956
Intra
SH2D4A Q9H788 RINT1 Homo sapiens Q6NUQ1
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 RINT1 Homo sapiens Q6NUQ1
Y2H Array
32296183
Intra
SH2D4A Q9H788 MAGEA11 Homo sapiens P43364
Pull Down
16189514
Intra
SH2D4A Q9H788 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 TRIM23 Homo sapiens P36406
Y2H Array
25416956
Intra
SH2D4A Q9H788 GRAP2 Homo sapiens O75791
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 GRAP2 Homo sapiens O75791
Y2H Array
32296183
Intra
SH2D4A Q9H788 LDOC1 Homo sapiens O95751
Y2H Array
31515488
Intra
SH2D4A Q9H788 LDOC1 Homo sapiens O95751
Y2H Prey Pooling
25416956
Intra
SH2D4A Q9H788 LDOC1 Homo sapiens O95751
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 LDOC1 Homo sapiens O95751
Y2H Array
32296183
Intra
SH2D4A Q9H788 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
25416956
Intra
SH2D4A Q9H788 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra
SH2D4A Q9H788 CFAP53 Homo sapiens Q96M91
Y2H Array
32296183
Intra
SH2D4A Q9H788 CFAP53 Homo sapiens Q96M91
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 IKZF1 Homo sapiens Q13422
Y2H Array
25416956
Intra
SH2D4A Q9H788 IKZF1 Homo sapiens Q13422
Y2H Prey Pooling
25416956
Intra
SH2D4A Q9H788 IKZF1 Homo sapiens Q13422
Validated Y2H
25416956
Intra
SH2D4A Q9H788 HCLS1 Homo sapiens P14317
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 HCLS1 Homo sapiens P14317
Y2H Array
32296183
Intra
SH2D4A Q9H788 HCLS1 Homo sapiens P14317
Y2H Array
25416956
Intra
SH2D4A Q9H788 HCLS1 Homo sapiens P14317
Y2H Array
31515488
Intra
SH2D4A Q9H788 ARC Homo sapiens Q7LC44
Y2H Array
32296183
Intra
SH2D4A Q9H788 ARC Homo sapiens Q7LC44
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 DBNL Homo sapiens Q9UJU6
Y2H Array
25416956
Intra
SH2D4A Q9H788 DBNL Homo sapiens Q9UJU6
Y2H Array
19060904
Intra
SH2D4A Q9H788 DBNL Homo sapiens Q9UJU6
Y2H Prey Pooling
25416956
Intra
SH2D4A Q9H788 DBNL Homo sapiens Q9UJU6
Y2H Pooling
19060904
Intra
SH2D4A Q9H788 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
SH2D4A Q9H788 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
SH2D4A Q9H788 TTC19 Homo sapiens Q6DKK2
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 TTC19 Homo sapiens Q6DKK2
Y2H Array
32296183
Intra
SH2D4A Q9H788 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
Intra
SH2D4A Q9H788 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 MORN3 Homo sapiens Q6PF18
Y2H Prey Pooling
32296183
Intra
SH2D4A Q9H788 MORN3 Homo sapiens Q6PF18
Y2H Array
32296183
Intra
SH2D4A Q9H788 MRFAP1 Homo sapiens Q9Y605
Validated Y2H
32296183
Intra
SH2D4A Q9H788 MRFAP1 Homo sapiens Q9Y605
Y2H Array
32296183
Intra
SH2D4A Q9H788 MRFAP1 Homo sapiens Q9Y605
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

SH2D4A 抗体

製品番号 製品名 アプリケーション 反応性
HY-P810095 SH2D4A Antibody (YA9439) WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA human
HY-P811086 SH2D4A Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS12825 SH2D4A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Canis familiaris SH2D4A VGNC VGNC:46114
Macaca mulatta SH2D4A VGNC VGNC:81568
Bos taurus SH2D4A VGNC VGNC:34560
Mus musculus SH2D4A MGD MGI:1919531
Rattus norvegicus SH2D4A RGD RGD:1307991
Felis catus SH2D4A VGNC VGNC:65095
Others SH2D4A NCBI