ARC - activity regulated cytoskeleton associated protein Gene

Also Known as hArc; Arg3.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23237

About ARC

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:142,611,049-142,614,479 (from NCBI)

This gene has 2 transcripts (splice variants) and 104 orthologues. Biased expression in adrenal (RPKM 5.5), brain (RPKM 5.4) and 9 other tissues.

Summary

Predicted to enable mRNA binding activity. Involved in cell migration; Cytoskeleton organization; and regulation of cell morphogenesis. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARC Products (2)

mRNA	Protein	Name
NM_001412852.1	NP_001399781.1	activity-regulated cytoskeleton-associated protein
NM_015193.5	NP_056008.1	activity-regulated cytoskeleton-associated protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables mRNA binding	IDA IDA: Inferred from direct assay	33175445	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables structural molecule activity	IDA IDA: Inferred from direct assay	33175445	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell migration	IMP IMP: Inferred from mutant phenotype	21834987	GOA
involved in cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	21834987	GOA
involved in regulation of cell morphogenesis	IMP IMP: Inferred from mutant phenotype	21834987	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21834987	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21834987	GOA
located in virus-like capsid	IDA IDA: Inferred from direct assay	33175445	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
activity-regulated cytoskeleton-associated protein	ARC/ARG3.1

ARC Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ARC	Q7LC44	SH2D4A	Homo sapiens	Q9H788	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Retrograde Amnesia	Amnesia, Retrograde
Amphetamine Abuse
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Amnestic Disorder	Amnesia Amnestic Syndrome Korsakoff'S Psychosis Or Syndrome Amnesic Syndrome Amnestic Disorder In Conditions Classified Elsewhere Korsakoff Psychosis Or Syndrome, Nonalcoholic Nonalcoholic Organic Amnesic Syndrome Organic Amnesic Syndrome
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10064	Ticagrelor	Antagonist	99.95%	Yes
HY-147080	Avacincaptad pegol sodium	Inhibitor	94.64%	Unkown
HY-B0678	Metaxalone		99.77%	Unkown
HY-19638	Cangrelor	Antagonist	/	Unkown
HY-B0678R	Metaxalone (Standard)		/	Unkown

Clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Phase
HY-153492A	Olpasiran sodium	Inhibitor	98.82%	Phase 3
HY-139142B	Simufilam hydrochloride		99.85%	Phase 3
HY-139142	Simufilam		99.78%	Phase 3
HY-139142A	Simufilam dihydrochloride		/	Phase 3
HY-135487	Sibenadet	Agonist	/	Phase 3
HY-147079	Egaptivon pegol	Inhibitor	92.75%	Phase 2
HY-153480A	ARC19499 sodium	Inhibitor	99.40%	Phase 1
HY-153480	ARC19499	Inhibitor	93.65%	Phase 1
HY-19845	Ordopidine	Antagonist	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (46)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13248	AR-C155858	Inhibitor	99.62%	Unkown
HY-110126	AR-C118925XX	Antagonist	≥99.0%	Unkown
HY-N2673	5-Heptadecylresorcinol	Activator	99.83%	Unkown
HY-78542	Deshydroxyethoxy ticagrelor	Inhibitor	98.82%	Unkown
HY-148826	Rovunaptabin		99.49%	Unkown
HY-12122A	AR-C102222 hydrochloride	Inhibitor	99.83%	Unkown
HY-59201A	A-582941 dihydrochloride		99.78%	Unkown
HY-126112	Mephenoxalone		98.57%	Unkown
HY-12709A	ARC 239 dihydrochloride	Antagonist	99.20%	Unkown
HY-147079A	Egaptivon pegol sodium	Inhibitor	92.75%	Unkown
HY-153098A	ARC186 sodium	Inhibitor	94.13%	Unkown
HY-77734	AR-C133913XX		99.76%	Unkown
HY-202191	ARC39	Inhibitor	98.5%	Unkown
HY-119996A	AR-C141990 hydrochloride	Inhibitor	98.2%	Unkown
HY-12709	ARC 239		99.71%	Unkown
HY-153098	ARC186	Inhibitor	94.13%	Unkown
HY-118942	Topovale	Inhibitor	99.94%	Unkown
HY-153785	NH2-C6-ARC186 sodium	Inhibitor	92.50%	Unkown
HY-108633	BYK 49187	Inhibitor	/	Unkown
HY-119996	AR-C141990	Inhibitor	/	Unkown
HY-122048	AR-C67085	Antagonist	/	Unkown
HY-124270	Sibenadet hydrochloride	Agonist	/	Unkown
HY-146769	Antimalarial agent 11	Inhibitor	/	Unkown
HY-148300	AR-C66096	Antagonist	/	Unkown
HY-148826A	Rovunaptabin sodium	Inhibitor	98.96%	Unkown
HY-153480C	ARC19499 sodium scrambled negative control	Inhibitor	/	Unkown
HY-153480D	FAM labled ARC19499 sodium		/	Unkown
HY-153480E	Cy3 labled ARC19499 sodium		/	Unkown
HY-153610	ARC7		99.57%	Unkown
HY-153611	ARC12		99.0%	Unkown
HY-172971	ARCher-142	Inhibitor	/	Unkown
HY-177800	ARC5690 sodium	Inhibitor	/	Unkown
HY-59201	A-582941		/	Unkown
HY-78542S	Deshydroxyethoxy Ticagrelor-d7		/	Unkown
HY-B0678S	Metaxalone-d3		98.0%	Unkown
HY-B0678S1	Metaxalone-d6		/	Unkown
HY-P10979	Buccalin		/	Unkown
HY-RS00890	ARC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09414	NOL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-10064S1	Ticagrelor-d4	Antagonist	/	Unkown
HY-114602	AR-C117977	Inhibitor	/	Unkown
HY-12122	AR-C102222	Inhibitor	/	Unkown
HY-RS17064	Arc Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18487	Nol3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23508	Arc Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24969	Nol3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ARC	VGNC	VGNC:26056
Macaca mulatta	ARC	VGNC	VGNC:69998
Rattus norvegicus	ARC	RGD	RGD:62037
Felis catus	ARC	VGNC	VGNC:105871
Mus musculus	ARC	MGD	MGI:88067
Others	ARC	NCBI