AR-C141990 hydrochloride
Based on 1 publication(s) in Google Scholar
AR-C141990 hydrochloride is a potent lactate transporters (monocarboxylate transporters; MCTs) inhibitor with pKi values of 7.6, 6.6 for MCT-1 and MCT-2, respectively. AR-C141990 hydrochloride has immunosuppressive properties and inhibits graft versus host response.
For research use only. We do not sell to patients.
- Purity: 98.2%
- CAS No.: 2250019-94-2
- Formula: C26H29ClN4O4S
- Molecular Weight:529.05
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) AR-C141990 hydrochloride
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Biological Activity
pKi: 7.6 (MCT-1) and 6.6 (MCT-2)[1]
AR-C141990 hydrochloride has no significant activity against MCT-3 (pIC50<5) or MCT-4 (pIC50<5)[1].
AR-C141990 hydrochloride inhibits the uptake of [3H]HOCPCA in oocytes expressing MCT1 or 2 in a concentration-dependent manner with IC50s of 0.21 µM and 2.32 µM, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application of the corresponding plasma concentrations of AR-C141990 hydrochloride (0.3-90 mg/kg) results in a concentration-dependent decrease in the B/P of HOCPCA with an EC50 of 860 ng/ml[2].
AR-C141990 (100 mg/kg; s.c.) has a moderate prolongation of graft survival for 40 days in PVG rats that received DA cardiac transplants[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2250019-94-2
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Appearance Solid
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Molecular Weight 529.05
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Formula C26H29ClN4O4S
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Color White to off-white
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SMILES
O=C1N(CC(C)C)C2=C(C(C(N3C[C@H](O)CC3)=O)=C(CC4=CC=NC5=CC=CC=C45)S2)C(N1C)=O.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Death Differ
Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and antitumor response. [Abstract]2023 Sep;30(9):2104-2119. PMID: 37582865
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Clara Påhlman, et al. Immunosuppressive Properties of a Series of Novel Inhibitors of the Monocarboxylate Transporter MCT-1. Transpl Int. 2013 Jan;26(1):22-9. [Content Brief]
[2]. Louise Thiesen, et al. In Vitro and In Vivo Evidence for Active Brain Uptake of the GHB Analog HOCPCA by the Monocarboxylate Transporter Subtype 1. J Pharmacol Exp Ther. 2015 Aug;354(2):166-74. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AR-C141990 hydrochloride Related Classifications
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