1. Membrane Transporter/Ion Channel
  2. Monocarboxylate Transporter
  3. AR-C141990 hydrochloride

AR-C141990 hydrochloride 

Cat. No.: HY-119996A
Handling Instructions

AR-C141990 hydrochloride is a potent lactate transporters (monocarboxylate transporters; MCTs) inhibitor with pKi values of 7.6, 6.6 for MCT-1 and MCT-2, respectively. AR-C141990 hydrochloride has immunosuppressive properties and inhibits graft versus host response.

For research use only. We do not sell to patients.

AR-C141990 hydrochloride Chemical Structure

AR-C141990 hydrochloride Chemical Structure

CAS No. : 2250019-94-2

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Description

AR-C141990 hydrochloride is a potent lactate transporters (monocarboxylate transporters; MCTs) inhibitor with pKi values of 7.6, 6.6 for MCT-1 and MCT-2, respectively[1]. AR-C141990 hydrochloride has immunosuppressive properties and inhibits graft versus host response[2].

IC50 & Target

pKi: 7.6 (MCT-1) and 6.6 (MCT-2)[1]

In Vitro

AR-C141990 hydrochloride has no significant activity against MCT-3 (pIC50<5) or MCT-4 (pIC50<5)[1].
AR-C141990 hydrochloride inhibits the uptake of [3H]HOCPCA in oocytes expressing MCT1 or 2 in a concentration-dependent manner with IC50s of 0.21 µM and 2.32 µM, respectively[2].

In Vivo

AR-C141990 hydrochloride (10 mg/kg; SC) with a parallel decline in plasma concentrations with a half-life around 20 minutes in male NMRI mice (18-22 g) [2].
Application of the corresponding plasma concentrations of AR-C141990 hydrochloride (0.3-90 mg/kg) results in a concentration-dependent decrease in the B/P of HOCPCA with an EC50 of 860 ng/ml[2].
AR-C141990 (100 mg/kg; s.c.) has a moderate prolongation of graft survival for 40 days in PVG rats that received DA cardiac transplants[1].

Molecular Weight

529.05

Formula

C₂₆H₂₉ClN₄O₄S

CAS No.

2250019-94-2

SMILES

O=C1N(CC(C)C)C2=C(C(C(N3C[[email protected]](O)CC3)=O)=C(CC4=CC=NC5=CC=CC=C45)S2)C(N1C)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

AR-C141990Monocarboxylate TransporterlactatetransportersMCTsMCT-1MCT-2immunosuppressivepropertiesgraftversushostresponseInhibitorinhibitorinhibit

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AR-C141990 hydrochloride
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HY-119996A
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