HIV-IN-14
HIV-IN-14 is an agent that binds to the HIV-1 reverse transcriptase p66 domain (monomeric GAG-POL), and also acts as a selective cytotoxic agent. HIV-IN-14 promotes GAG-POL dimerization, which in turn leads to premature activation of intracellular viral protease. HIV-IN-14 selectively kills HIV-infected cells expressing GAG-POL without exerting cytotoxicity on non-HIV-infected cells. HIV-IN-14 can be used in the research of HIV infection, acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC).
For research use only. We do not sell to patients.
- CAS No.: 3069129-78-5
- Formula: C22H19F3N4O2
- Molecular Weight:428.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HIV-1 |
HIV-IN-14 (Compound 40) exhibits an EC50 value of 5.9 nM in HIV-TACK activity assays[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3069129-78-5
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Molecular Weight 428.41
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Formula C22H19F3N4O2
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SMILES
O=C1N[C@@](C(F)(F)C)(C#CC2CC2)C3=C(C=C(CN4C(C(NC5)=O)=C5C=C4)C(F)=C3)N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HIV-IN-14 Related Classifications
HY-184492 Related Classifications
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