3069129-78-5
Chemical Structure
HIV-IN-14
- CAS. Nr.: 3069129-78-5
- Formula:C22H19F3N4O2
- Molecular Weight:428.41
InChIKey: FIHCJHWOFWPCNM-QFIPXVFZSA-N
SMILES: O=C1N[C@@](C(F)(F)C)(C#CC2CC2)C3=C(C=C(CN4C(C(NC5)=O)=C5C=C4)C(F)=C3)N1
Biological Activity: HIV-IN-14 is an agent that binds to the HIV-1 reverse transcriptase p66 domain (monomeric GAG-POL), and also acts as a selective cytotoxic agent. HIV-IN-14 promotes GAG-POL dimerization, which in turn leads to premature activation of intracellular viral protease. HIV-IN-14 selectively kills HIV-infected cells expressing GAG-POL without exerting cytotoxicity on non-HIV-infected cells. HIV-IN-14 can be used in the research of HIV infection, acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC)[1].
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HIV-IN-14 | HIV-IN-14 is an agent that binds to the HIV-1 reverse transcriptase p66 domain (monomeric GAG-POL), and also acts as a selective cytotoxic agent. HIV-IN-14 promotes GAG-POL dimerization, which in turn leads to premature activation of intracellular viral protease. HIV-IN-14 selectively kills HIV-infected cells expressing GAG-POL without exerting cytotoxicity on non-HIV-infected cells. HIV-IN-14 can be used in the research of HIV infection, acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC). | |||||||||||||||||||||
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