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Cat. No.: HY-184924

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HIV-IN-15

HIV-IN-15 is a HIV-infected cell killer, with an EC₅₀ of 20 nM in the HIV-TACK assay. HIV-IN-15 binds to the reverse transcriptase p66 domain of monomeric GAG-POL, accelerates the dimerization process, and selectively kills HIV-infected cells expressing GAG-POL, with no cytotoxicity against HIV-uninfected cells. HIV-IN-15 can be used for research on HIV infection, acquired immunodeficiency syndrome (AIDS), or AIDS-related complex (ARC).

For research use only. We do not sell to patients.

CAS No.: 3102264-65-0
Formula: C₂₁H₁₃Cl₂F₅N₄O₅
Molecular Weight:567.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HIV-IN-15 Chemical Structure

CAS No.: 3102264-65-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All HIV Isoforms :

In Vitro

HIV-IN-15 (Compound 45) inhibits TACK in HIV-TACK activity assays with an EC₅₀ of 20 nM, and promotes GAG-POL dimerization to induce HIV-1 cell death^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3102264-65-0
Molecular Weight 567.25
Formula C₂₁H₁₃Cl₂F₅N₄O₅
SMILES

ClC1=CC(C#N)=C(F)C(OC2=C(C(C(F)F)(F)F)N=CN(CC3=[N+]([O-])C=C(OCCO)C(Cl)=C3)C2=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sabnis R W. Novel N-Oxide Derivatives for Treating HIV Infection or AIDS or AIDS Related Complex[J]. ACS Medicinal Chemistry Letters, 2026.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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