3102264-65-0
Chemical Structure
HIV-IN-15
- CAS. Nr.: 3102264-65-0
- Formula:C21H13Cl2F5N4O5
- Molecular Weight:567.25
InChIKey: GCMLHQRCAPFLLA-UHFFFAOYSA-N
SMILES: ClC1=CC(C#N)=C(F)C(OC2=C(C(C(F)F)(F)F)N=CN(CC3=[N+]([O-])C=C(OCCO)C(Cl)=C3)C2=O)=C1
Biological Activity: HIV-IN-15 is a HIV-infected cell killer, with an EC50 of 20 nM in the HIV-TACK assay. HIV-IN-15 binds to the reverse transcriptase p66 domain of monomeric GAG-POL, accelerates the dimerization process, and selectively kills HIV-infected cells expressing GAG-POL, with no cytotoxicity against HIV-uninfected cells. HIV-IN-15 can be used for research on HIV infection, acquired immunodeficiency syndrome (AIDS), or AIDS-related complex (ARC)[1].
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HIV-IN-15 | HIV-IN-15 is a HIV-infected cell killer, with an EC50 of 20 nM in the HIV-TACK assay. HIV-IN-15 binds to the reverse transcriptase p66 domain of monomeric GAG-POL, accelerates the dimerization process, and selectively kills HIV-infected cells expressing GAG-POL, with no cytotoxicity against HIV-uninfected cells. HIV-IN-15 can be used for research on HIV infection, acquired immunodeficiency syndrome (AIDS), or AIDS-related complex (ARC). | |||||||||||||||||||||
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Keywords
