GRAMD4 - GRAM domain containing 4 Gene

Also Known as DIP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23151

Summary

GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced Apoptosis (Stanelle et al., 2005 [PubMed 15565177]).[supplied by OMIM, Jan 2011]
Ubiquitous expression in colon (RPKM 10.9), small intestine (RPKM 9.6) and 25 other tissues.

GRAMD4 Products (2)

mRNA Protein Name
NM_001366660.1 NP_001353589.1 GRAM domain-containing protein 4 isoform 2
NM_015124.5 NP_055939.1 GRAM domain-containing protein 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
15565177 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
15565177 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRAMD4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GRAMD4 Q6IC98 FAM9B Homo sapiens Q8IZU0
Validated Y2H
32296183
Intra
GRAMD4 Q6IC98 CCDC146 Homo sapiens Q8IYE0
Validated Y2H
32296183
Intra
GRAMD4 Q6IC98 SMARCD1 Homo sapiens Q96GM5
Validated Y2H
32296183
Intra
GRAMD4 Q6IC98 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
GRAMD4 Q6IC98 EXOC8 Homo sapiens Q8IYI6
Validated Y2H
32296183
Intra
GRAMD4 Q6IC98 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
Intra
GRAMD4 Q6IC98 MTMR9 Homo sapiens Q96QG7
Validated Y2H
32296183
Intra
GRAMD4 Q6IC98 SH2D4A Homo sapiens Q9H788
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05772 GRAMD1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05773 GRAMD1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05774 GRAMD1C Human Pre-designed siRNA Set A Pre-designed Set / Unkown