C1QC - complement C1q C chain Gene

Also Known as C1QG; C1Q-C

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 714

About C1QC

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:22,643,633-22,648,108 (from NCBI)

This gene has 8 transcripts (splice variants), 168 orthologues, 23 paralogues and is associated with 2 phenotypes. Broad expression in spleen (RPKM 519.1), lymph node (RPKM 141.4) and 14 other tissues.

Summary

This gene encodes the C-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum Complement System. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. [provided by RefSeq, Dec 2016]

C1QC Products (4)

mRNA Protein Name
NM_001114101.3 NP_001107573.1 complement C1q subcomponent subunit C isoform 1 precursor
NM_001347619.2 NP_001334548.1 complement C1q subcomponent subunit C isoform 1 precursor
NM_001347620.2 NP_001334549.1 complement C1q subcomponent subunit C isoform 2
NM_172369.5 NP_758957.2 complement C1q subcomponent subunit C isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
28018340 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in complement activation, classical pathway IDA
IDA: Inferred from direct assay
29449492 GOA
involved in negative regulation of granulocyte differentiation IDA
IDA: Inferred from direct assay
10961870 GOA
involved in negative regulation of macrophage differentiation IDA
IDA: Inferred from direct assay
10961870 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
part of complement component C1q complex IPI
IPI: Inferred from physical interaction
29449492 GOA
located in extracellular region IDA
IDA: Inferred from direct assay
18250442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C1QC Protein Structure

Collagen

Collagen: Collagen triple helix repeat (20 copies) (31 - 67)

Collagen

Collagen: Collagen triple helix repeat (20 copies) (66 - 113)

C1q

C1q: C1q domain (121 - 242)

  • 0
  • 100
  • 200
  • 245 a.a.
Protein Preferred Names Protein Names

complement C1q subcomponent subunit C

  • complement component 1, q subcomponent, C chain

C1QC Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
C1QC P02747 Q07021-PRO_0000018590 Homo sapiens Q07021-PRO_0000018590
ELISA
28018340
Intra
C1QC P02747 ZNF534 Homo sapiens Q76KX8
Validated Y2H
32296183
Intra
C1QC P02747 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
C1QC P02747 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
C1QC P02747 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
C1q Deficiency

  • C1QD

  • Complement Component C1q Deficiency
Immunodeficiency Due To A Classical Component Pathway Complement Deficiency

  • Immunodeficiency Due To C1, C4, Or C2 Component Complement Deficiency

  • Immunodeficiency Due To An Early Component Of Complement Deficiency
Glomerulonephritis

  • Bright'S Disease
Lupus Erythematosus

  • Lupus

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus, Systemic

  • Subacute Cutaneous Lupus

  • Le - [Lupus Erythematosus]
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Angioedema, Hereditary, 1

  • Hereditary Angioedema Type I

  • Hereditary Angioneurotic Edema

  • Hane

  • C1 Esterase Inhibitor Deficiency

  • Angioedema, Hereditary, 1 And 2

  • HAE1

  • Angioneurotic Edema, Hereditary

  • Angioedema, Hereditary, Type I

  • Hereditary Angioedema Type 2

  • Hae 2

  • Hae-Ii

  • Hereditary Angioneurotic Edema Type 2

  • Angioedema, Hereditary

  • HAE

  • Angioedema, Hereditary, Types I And Ii

  • Hereditary Angioedema, Type Ii

  • Angioedema, Hereditary, Type 1

  • Angioedemas, Hereditary

  • Hereditary C1 Esterase Inhibitor Deficiency - Dysfunctional Factor

  • Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor

  • Hereditary Angioedema Types I And Ii
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS01721 C1QC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19879 C1qc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26378 C1qc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Canis familiaris C1QC VGNC VGNC:52112
Bos taurus C1QC VGNC VGNC:26619
Macaca mulatta C1QC VGNC VGNC:99857
Rattus norvegicus C1QC RGD RGD:1306828
Mus musculus C1QC MGD MGI:88225
Felis catus C1QC VGNC VGNC:107491
Others C1QC NCBI