HROB - homologous recombination factor with OB-fold Gene

Also Known as MCM8IP; C17orf53

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 78995

About HROB

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:44,141,930-44,162,476 (from NCBI)

This gene has 5 transcripts (splice variants) and 188 orthologues. Broad expression in testis (RPKM 4.5), bone marrow (RPKM 2.8) and 14 other tissues.

Summary

Predicted to enable single-stranded DNA binding activity. Involved in DNA synthesis involved in DNA repair and interstrand cross-link repair. Located in site of DNA damage. [provided by Alliance of Genome Resources, Apr 2022]

HROB Products (4)

mRNA Protein Name
NM_001171251.3 NP_001164722.1 homologous recombination OB-fold protein isoform 2
NM_001321310.2 NP_001308239.1 homologous recombination OB-fold protein isoform 3
NM_001321311.2 NP_001308240.1 homologous recombination OB-fold protein isoform 4
NM_024032.5 NP_076937.2 homologous recombination OB-fold protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
31467087 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
31467087 GOA
involved in DNA synthesis involved in DNA repair IMP
IMP: Inferred from mutant phenotype
31467087 GOA
involved in interstrand cross-link repair IMP
IMP: Inferred from mutant phenotype
31467087 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in site of DNA damage IMP
IMP: Inferred from mutant phenotype
31467087 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homologous recombination OB-fold protein

  • MCM8-9-Interacting Protein)

HROB 抗体

製品番号 製品名 アプリケーション 反応性
HY-P84670 C17ORF53 Antibody (YA4367) ICC/IF, FC, ELISA Human
HY-P84670A C17ORF53 Antibody (YA4367)(PBS only) ICC/IF, FC, ELISA Human

関連疾患

Diseases Alias
Premature Menopause

  • Primary Ovarian Insufficiency

  • Premature Ovarian Failure

  • Hypergonadotropic Hypogonadism

  • Premature Ovarian Insufficiency

  • Menopause - Premature

  • Menopause Praecox

  • Menopause Premature

  • Menopause, Premature

  • Female Hypergonadotropic Hypogonadism

  • Hypergonadotrophic Ovarian Failure

  • Primary Female Hypogonadism

  • Pof - [Premature Ovarian Failure]

  • Ovarian Failure

  • Ovarian Secretion Suppression

  • Ovary Hyposecretion

  • Ovary Secretion Deficiency

  • Premature Menopause Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS06373 HROB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17246 Hrob Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23700 Hrob Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta HROB VGNC VGNC:70421
Bos taurus HROB VGNC VGNC:52654
Felis catus HROB VGNC VGNC:60725
Rattus norvegicus HROB RGD RGD:1305385
Canis familiaris HROB VGNC VGNC:49206
Mus musculus HROB MGD MGI:2387601
Others HROB NCBI