CTU1 - cytosolic thiouridylase subunit 1 Gene

Also Known as NCS6; ATPBD3

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 90353

About CTU1

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,097,606-51,108,409 (from NCBI)

This gene has 1 transcript (splice variant) and 179 orthologues. Ubiquitous expression in kidney (RPKM 1.5), spleen (RPKM 1.3) and 25 other tissues.

Summary

Predicted to enable tRNA binding activity. Predicted to be involved in tRNA wobble position Uridine thiolation. Predicted to be located in cytosol. Predicted to be part of cytosolic tRNA wobble base thiouridylase complex. [provided by Alliance of Genome Resources, Apr 2022]

CTU1 Products (1)

mRNA Protein Name
NM_145232.4 NP_660275.2 cytoplasmic tRNA 2-thiolation protein 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
19017811 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTU1 Protein Structure

ATP_bind_3

ATP_bind_3: PP-loop family (54 - 240)

  • 0
  • 100
  • 200
  • 300
  • 348 a.a.
Protein Preferred Names Protein Names

cytoplasmic tRNA 2-thiolation protein 1

  • ATP binding domain 3

CTU1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
CTU1 Q7Z7A3 URM1 Homo sapiens Q9BTM9
Anti Tag CoIP
19017811
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Neuropathy, Hereditary Sensory And Autonomic, Type Iii

  • Familial Dysautonomia

  • Riley-Day Syndrome

  • Dysautonomia, Familial

  • HSAN3

  • Hsan Iii

  • Fd

  • Hereditary Sensory And Autonomic Neuropathy Type Iii

  • Dys

  • Hereditary Sensory And Autonomic Neuropathy 3

  • Riley Day Syndrome

  • Familial Autonomic Nervous Dysfunction

  • Hereditary Sensory Autonomic Neuropathy Type Iii

  • Hsan 3

  • Hsn 3

  • Hereditary Sensory Neuropathy Type 3

  • Hsan Type Iii

  • Hsn-Iii

  • Hereditary Sensory And Autonomic Neuropathy Type 3

  • Neuropathy, Hereditary Sensory And Autonomic, 3

  • Hsn Iii

  • Dysautonomia Familial

  • Neuropathy, Sensory And Autonomic, Hereditary, Type Iii

  • Hsan3 - [Hereditary Sensory And Autonomic Neuropathy Type 3]
Spinal Cord Ependymoma

  • Ependymal Neoplasm Of The Spinal Cord

  • Spinal Ependymoma

  • Ependymoma Of Spinal Cord
Dubowitz Syndrome

  • Dubowitz'S Syndrome

  • Dwarfism-Eczema-Peculiar Facies Syndrome

  • Intrauterine Growth Restriction, Short Stature, Microcephaly, Mild Intellectual Disability With Behavior Problems, Eczema, And Unusual And Distinctive Faci
Benign Epilepsy With Centrotemporal Spikes

  • Rolandic Epilepsy

  • Benign Rolandic Epilepsy

  • Epilepsy, Rolandic

  • Bcects

  • Benign Childhood Epilepsy With Centrotemporal Spike

  • Sylvan Seizures

  • Becrs

  • Bects

  • Bre

  • Benign Epilepsy Of Childhood With Centrotemporal Spikes

  • Benign Familial Epilepsy Of Childhood With Rolandic Spikes

  • Centrotemporal Epilepsy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS03353 CTU1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus CTU1 MGD MGI:2385277
Macaca mulatta CTU1 VGNC VGNC:109612
Rattus norvegicus CTU1 RGD RGD:1308740
Others CTU1 NCBI