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DGKI - diacylglycerol kinase iota Gene

Also Known as DGK-IOTA

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 9162

About DGKI

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:137,381,037-137,846,974 (from NCBI)

This gene has 13 transcripts (splice variants), 223 orthologues and 9 paralogues. Biased expression in thyroid (RPKM 5.1), brain (RPKM 1.6) and 1 other tissue.

Summary

This gene is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol Kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration. [provided by RefSeq, Jul 2008]

DGKI Products (5)

mRNA	Protein	Name
NM_001321708.2	NP_001308637.1	diacylglycerol kinase iota isoform 2
NM_001321709.2	NP_001308638.1	diacylglycerol kinase iota isoform 3
NM_001321710.2	NP_001308639.1	diacylglycerol kinase iota isoform 4
NM_001388092.1	NP_001375021.1	diacylglycerol kinase iota isoform 5
NM_004717.3	NP_004708.1	diacylglycerol kinase iota isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables ATP-dependent diacylglycerol kinase activity	IDA IDA: Inferred from direct assay	9830018	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17986458	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in lipid phosphorylation	IDA IDA: Inferred from direct assay	9830018	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in cytoplasm	IDA IDA: Inferred from direct assay	9830018	GOA
located in dendritic spine	IDA IDA: Inferred from direct assay	21119615	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9830018	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	21119615	GOA
located in synapse	IDA IDA: Inferred from direct assay	21119615	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DGKI Protein Structure

C1_1

DAGK_cat

DAGK_acc

Ank_2

0
200
400
600
800
1000
1065 a.a.

Protein Preferred Names	Protein Names
diacylglycerol kinase iota	DAG kinase iota

DGKI Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	DGKI	O75912	VHL	Homo sapiens	P40337-3	Y2H	17986458
Intra	DGKI	O75912	VHL	Homo sapiens	P40337-3	Anti Tag CoIP	17986458

Cross: Cross-species interaction Intra: Intraspecies interaction

Diseases	Alias
Dyslexia
Retinal Degeneration	Degeneration Of Retina

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS03721	DGKI Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22136	Dgki Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28657	Dgki Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Felis catus	DGKI	VGNC	VGNC:61461
Mus musculus	DGKI	MGD	MGI:2443430
Bos taurus	DGKI	VGNC	VGNC:28030
Macaca mulatta	DGKI	VGNC	VGNC:71787
Canis familiaris	DGKI	VGNC	VGNC:39921
Rattus norvegicus	DGKI	RGD	RGD:735049
Others	DGKI	NCBI