DGKI - diacylglycerol kinase iota Gene

Also Known as DGK-IOTA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9162

About DGKI

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:137,381,037-137,846,974 (from NCBI)

This gene has 13 transcripts (splice variants), 223 orthologues and 9 paralogues. Biased expression in thyroid (RPKM 5.1), brain (RPKM 1.6) and 1 other tissue.

Summary

This gene is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration. [provided by RefSeq, Jul 2008]

DGKI Products (5)

mRNA Protein Name
NM_001321708.2 NP_001308637.1 diacylglycerol kinase iota isoform 2
NM_001321709.2 NP_001308638.1 diacylglycerol kinase iota isoform 3
NM_001321710.2 NP_001308639.1 diacylglycerol kinase iota isoform 4
NM_001388092.1 NP_001375021.1 diacylglycerol kinase iota isoform 5
NM_004717.3 NP_004708.1 diacylglycerol kinase iota isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP-dependent diacylglycerol kinase activity IDA
IDA: Inferred from direct assay
9830018 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17986458 GOA
Biological Process GO Annotation Evidence References Source
involved in lipid phosphorylation IDA
IDA: Inferred from direct assay
9830018 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9830018 GOA
located in dendritic spine IDA
IDA: Inferred from direct assay
21119615 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9830018 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
21119615 GOA
located in synapse IDA
IDA: Inferred from direct assay
21119615 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DGKI Protein Structure

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (251 - 310)

DAGK_cat

DAGK_cat: Diacylglycerol kinase catalytic domain (376 - 500)

DAGK_acc

DAGK_acc: Diacylglycerol kinase accessory domain (526 - 683)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (963 - 1048)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1065 a.a.
Protein Preferred Names Protein Names

diacylglycerol kinase iota

  • DAG kinase iota

DGKI Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DGKI O75912 VHL Homo sapiens P40337-3
Y2H
17986458
Intra
DGKI O75912 VHL Homo sapiens P40337-3
Anti Tag CoIP
17986458
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Dyslexia
Retinal Degeneration

  • Degeneration Of Retina
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03721 DGKI Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22136 Dgki Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28657 Dgki Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DGKI VGNC VGNC:61461
Mus musculus DGKI MGD MGI:2443430
Bos taurus DGKI VGNC VGNC:28030
Macaca mulatta DGKI VGNC VGNC:71787
Canis familiaris DGKI VGNC VGNC:39921
Rattus norvegicus DGKI RGD RGD:735049
Others DGKI NCBI