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製品番号: HY-163430

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HDAC-IN-71

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

HDAC-IN-71 (Compound 17q) is a potent HDAC inhibitor with IC₅₀ values of 12.6, 14.1, 20, 3, and 72 nM for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC10, respectively. HDAC-IN-71 induces apoptosis and can be used in cancer research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2995354-52-2
分子式: C₁₉H₂₄N₂O₅
分子量:360.40

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

HDAC-IN-71 構造式

CAS 番号: 2995354-52-2

容量

価格（税別）

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数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
- 体内実験
化学情報
Publications (1)
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

HDAC1

12.6 nM (IC₅₀)

HDAC2

14.1 nM (IC₅₀)

HDAC3

20 nM (IC₅₀)

HDAC6

3 nM (IC₅₀)

HDAC10

72 nM (IC₅₀)

HDAC アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.39 μM Compound: 17q	Antiproliferative activity against human A549 cells incubated for 96 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 96 hrs by MTT assay	[PMID: 38503167]
DU-145	IC₅₀	0.16 μM Compound: 17q	Antiproliferative activity against human DU-145 cells incubated for 96 hrs by MTT assay Antiproliferative activity against human DU-145 cells incubated for 96 hrs by MTT assay	[PMID: 38503167]
HCT-116	IC₅₀	0.47 μM Compound: 17q	Antiproliferative activity against human HCT-116 cells incubated for 96 hrs by MTT assay Antiproliferative activity against human HCT-116 cells incubated for 96 hrs by MTT assay	[PMID: 38503167]
HT-29	IC₅₀	1.05 μM Compound: 17q	Antiproliferative activity against human HT-29 cells incubated for 96 hrs by MTT assay Antiproliferative activity against human HT-29 cells incubated for 96 hrs by MTT assay	[PMID: 38503167]
LNCaP	IC₅₀	0.63 μM Compound: 17q	Antiproliferative activity against human LNCaP cells incubated for 96 hrs by MTT assay Antiproliferative activity against human LNCaP cells incubated for 96 hrs by MTT assay	[PMID: 38503167]
MCF7	IC₅₀	0.35 μM Compound: 17q	Antiproliferative activity against human MCF7 cells incubated for 96 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 96 hrs by MTT assay	[PMID: 38503167]
MDA-MB-231	IC₅₀	0.31 μM Compound: 17q	Antiproliferative activity against human MDA-MB-231 cells incubated for 96 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells incubated for 96 hrs by MTT assay	[PMID: 38503167]
NCI-H1650	IC₅₀	3.56 μM Compound: 17q	Antiproliferative activity against human NCI-H1650 cells incubated for 96 hrs by MTT assay Antiproliferative activity against human NCI-H1650 cells incubated for 96 hrs by MTT assay	[PMID: 38503167]
NCI-H446	IC₅₀	0.65 μM Compound: 17q	Antiproliferative activity against human NCI-H446 cells incubated for 96 hrs by MTT assay Antiproliferative activity against human NCI-H446 cells incubated for 96 hrs by MTT assay	[PMID: 38503167]
PC-3	IC₅₀	0.72 μM Compound: 17q	Antiproliferative activity against human PC-3 cells incubated for 96 hrs by MTT assay Antiproliferative activity against human PC-3 cells incubated for 96 hrs by MTT assay	[PMID: 38503167]

体外実験

HDAC-IN-71 (0-1.6 μM; 24 h) inhibits colony formation in a dose-dependent manner and completely inhibits colony formation of DU145 cells at a concentration of 3.2 μM^[1].
HDAC-IN-71 (0-1.6 μM; 72 h) arrests cells in G2/M phase and induces apoptosis in DU145 cell line in a concentration-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:

DU145 cells
Concentration:

0, 0.2, 0.4, 0.8, 1.6 μM
Incubation Time:

12 h
Result:

Inhibited cancer cell migration.

Cell Cycle Analysis^[1]

Cell Line:

DU145 cells
Concentration:

0, 0.2, 0.4, 0.8, 1.6 μM
Incubation Time:

72 h
Result:

Arrested cells in G2/M phase in a dose-dependent manner.

Western Blot Analysis^[1]

Cell Line:

DU145 cells
Concentration:

0.8, 1.6, 3.2 μM
Incubation Time:

24 h
Result:

Induced histone acetylation and inhibited HDAC6 expression.

体内実験

HDAC-IN-71 (100, 200 mg/kg; p.o.; daily; 40 days) inhibits tumor growth at concentrations of 100 mg/kg and 200 mg/kg, with TGI values of 50.92% and 68.00% respectively^[1].
Pharmacokinetic analysis^[1]

Parameters	I.V. (2 mg/kg)	P.O. (10 mg/kg)
AUC_0-∞ (h ng/mL)	1633.35	3799.46
T_1/2 (h)	3.12	2.87
CL (L/h/kg)	1.57
V (L/kg)	4.63
C_max(ng/mL)	851.5	774.0
F		46.52%

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Balb/c nude mice^[1]
Dosage:

100, 200 mg/kg
Administration:

Oral administration; daily; 40 days
Result:

Significantly inhibited prostate cancer (PCa) tumor growth.

化学情報

CAS 番号 2995354-52-2
分子量 360.40
分子式 C₁₉H₂₄N₂O₅
SMILES

COC1=C(C=CC=C1)/C=C2CC(N(C\2=O)CCCCCCC(NO)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

Int J Parasitol Drugs Drug Resist

2026 May 17;31:100649.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Jiang Q, et al. Discovery of novel itaconimide-based derivatives as potent HDAC inhibitors for the efficient treatment of prostate cancer. Eur J Med Chem. 2024 Apr 5;269:116315. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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HDAC-IN-71

1 Cited Publications

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
Publications (1)
純度とドキュメンテーション
参考文献

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HDAC-IN-71

MedChemExpress（MCE）の使用を引用している文献 HDAC-IN-71

HDAC アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

HDAC-IN-71 関連分類

HY-163430 関連分類