Partricin A
Partricin A is an antimicrobial agent with affinity for ergosterol and cholesterol. Partricin A inhibits growth of fungal species and Trichomonas vaginalis. Partricin A induces hemolysis of rat erythrocytes. Partricin A causes acute toxicity in mice via intraperitoneal or intravenous administration. Partricin A serves as a starting material for synthesis of semisynthetic amide derivatives. Partricin A can be used for the research of fungal infections, trichomonas vaginalis infection.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 76551-64-9
- 分子式: C59H86N2O19
- 分子量:1127.32
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Partricin A (serial dilutions; 24-48 h) inhibits growth of Candida albicans strains LRM 73, LRM 200, and LRM 205 with minimum inhibitory concentrations ranging from 30 ng/mL (24 h, LB) to 120 ng/mL (48 h, SB)[1].
Partricin A (serial dilutions; 7 h) inhibits 50% of Saccharomyces cerevisiae LRM 167 growth with an IC50 of 2.1 ng/mL after 7 h incubation in liquid medium[1].
Partricin A (serial dilutions; 24-48 h, 4 days, 5 days) inhibits growth of Mucor sp. LRM 263 (MIC 1.2-2.4 μg/mL), Aspergillus niger LRM 374 (MIC 2.4 μg/mL), and Trichophyton mentagrophytes LRM 176 (MIC 2.4 μg/mL) in solid or liquid culture media[1].
Partricin A (serial dilutions; 48 h) inhibits growth of Trichomonas vaginalis LRM 415 with an MIC of 0.075 μg/mL after 48 h incubation in semisolid medium[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD1 (male, 4-5 weeks old, 14-18 g)[1]
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Dosage:0.6 mg/kg
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Administration:i.p.
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Result:Exhibited an intraperitoneal LD50 of 0.6 mg/kg.
化学情報
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CAS 番号 76551-64-9
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分子量 1127.32
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分子式 C59H86N2O19
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SMILES
O=C(O[C@H]([C@@H](C)CC[C@@H](O)CC(C1=CC=C(NC)C=C1)=O)[C@@H](C)/C=C/C=C/C=C\C=C/C=C/C=C/C=C/[C@H](O[C@H]2[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O2)C3)C[C@H](O)CC(C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@]4(O)C[C@H](O)[C@@H](C(O)=O)[C@H]3O4)=O
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Structure Classification
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Initial Source
Streptomyces aureofaciens
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Partricin A 関連分類
HY-N21836 関連分類
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