PF-06422913
PF-06422913 is an orally active, potent and selective metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1539296-46-2
- 分子式: C18H13F3N6O
- 分子量:386.33
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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mGlu5 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
4.8 nM
Compound: 15
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Negative allosteric modulation of rat mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium flux after 16 to 24 hrs by FLIPR assay
Negative allosteric modulation of rat mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium flux after 16 to 24 hrs by FLIPR assay
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[PMID: 24392688] |
化学情報
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CAS 番号 1539296-46-2
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分子量 386.33
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分子式 C18H13F3N6O
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SMILES
FC(F)(C1=C(C2=NN(C)C3=C2N=CC(OCC4=NC=CC=C4)=N3)C=NC=C1)F
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PF-06422913 関連分類
HY-135441 関連分類
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