5486 Results for "

Formic Acid

" in MedChemExpress (MCE) Product Catalog:
Products (5486)

5486 Results for "Formic Acid" in MCE Product Catalog:

755
Z-VAD-FMK
Z-VAD-FMK
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755 Publications Verification
製品番号: HY-16658B
CAS 番号: 161401-82-7
別名: Z-VAD(OH)-FMK
Target:  

Caspase Apoptosis RIP kinase Glutathione Peroxidase Reactive Oxygen Species (ROS)

研究分野:  

Inflammation/Immunology Cancer

Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .
666
Acetylcysteine
Acetylcysteine
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666 Cited Publications
製品番号: HY-B0215
CAS 番号: 616-91-1
別名: N-Acetylcysteine; N-Acetyl-L-cysteine; NAC
Category:  

Ketones, Aldehydes, Acids Endogenous metabolite

Target:  

Reactive Oxygen Species (ROS) Endogenous Metabolite Apoptosis Ferroptosis Influenza Virus Disulfidptosis

Acetylcysteine (N-Acetylcysteine) is a mucolytic agent that can cross the blood-brain barrier, which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine ​​is the most stable form of cysteine ​​during drug delivery and can be used in disulfidptosis studies .
395
PD98059
PD98059
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395 Cited Publications
製品番号: HY-12028
CAS 番号: 167869-21-8
純度:  98.89%
Target:  

MEK ERK Aryl Hydrocarbon Receptor Autophagy

研究分野:  

Cancer

PD98059 is a potent and selective MEK inhibitor with an IC50 of 5 µM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC50 of 2-7 µM) and MEK2 (IC50 of 50 µM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC50 of 4 μM) and AHR transformation (IC50 of 1 μM). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced autophagy .
360
Dexamethasone (Water Soluble)
Dexamethasone (Water Soluble)
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360 Cited Publications
製品番号: HY-14648C
CAS 番号: 50-02-2
純度:  ≥98.0%
別名: Dexamethasone cyclodextrin complex
Target:  

Exosomes Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic

研究分野:  

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Dexamethasone (Hexadecadrol) Water Soluble is a water-soluble form of Dexamethasone (HY-14648). Dexamethasone is a glucocorticoid receptor agonist, apoptosis inducer, and a common disease inducer in experimental animals. It can be used to construct models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has the potential to be used in COVID-19 research .(Sale size is the weight of dexamethasone)
296
Trametinib (DMSO solvate)
Trametinib (DMSO solvate)
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296 Cited Publications
製品番号: HY-10999A
CAS 番号: 1187431-43-1
純度:  99.56%
別名: GSK-1120212 (DMSO solvate); JTP-74057 (DMSO solvate)
Target:  

MEK Apoptosis

研究分野:  

Cancer

Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib (DMSO solvate) activates autophagy and induces apoptosis . This product is in solid form, a DMSO solvate, and a stable crystalline form.
217
JC-1
JC-1
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217 Cited Publications
製品番号: HY-15534
CAS 番号: 3520-43-2
純度:  98.71%
別名: CBIC2
JC-1 (CBIC2) is an ideal fluorescent probe widely used to detect mitochondrial membrane potential. JC-1 accumulates in mitochondria in a potential dependent manner and can be used to detect the membrane potential of cells or purified mitochondria. In normal mitochondria, JC-1 aggregates in the mitochondrial matrix to form a polymer, which emits strong red fluorescence (Ex=585 nm, Em=590 nm); When the mitochondrial membrane potential is low, JC-1 cannot aggregate in the matrix of mitochondria and produce green fluorescence (ex=510 nm, em= 527 nm) .
189
PEG300
PEG300
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189 Cited Publications
製品番号: HY-Y0873
CAS 番号: 25322-68-3
別名: Polyethylene glycol 300
PEG300 (Polyethylene glycol 300), a neutral polymer of molecular weight 300, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol .
171
Dihydroethidium
Dihydroethidium
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171 Cited Publications
製品番号: HY-D0079
CAS 番号: 104821-25-2
別名: Hydroethidine; PD-MY 003
Dihydroethidium, also known as DHE, is a peroxide indicator. Dihydroethidium penetrates cell membranes to form a fluorescent protein complex with blue fluoresces. After entering the cells, Dihydroethidium is mainly localized in the cell membrane, cytoplasm and nucleus, and the staining effect is the strongest in the nucleus. Dihydroethidium produces inherent blue fluorescence with a maximum excitation wavelength of 370 nm and a maximum emission wavelength of 420 nm; after dehydrogenation, Dihydroethidium combines with RNA or DNA to produce red fluorescence with a maximum excitation wavelength of 300 nm and a maximum emission wavelength of 610 nm. 535 nm can also be used as the excitation wavelength for actual observation .
107
CFDA-SE
CFDA-SE
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107 Cited Publications
製品番号: HY-D0938
CAS 番号: 150347-59-4
別名: CFSE; 5(6)-Carboxyfluorescein diacetate succinimidyl ester; 5(6)-CFDA N-succinmidyl ester
CFDA-SE is a fluorescent dye that can penetrate the cell membrane. It can react with the free amine group in the cytoskeleton protein inside the cell, and finally form a protein complex with fluorescence. After entering the cell, CFDA-SE locates in the cell membrane, cytoplasm and nucleus, and the fluorescence staining is strongest in the nucleus . CFDA-SE dye can be uniformly inherited by the cells with cell division and proliferation, and its attenuation is proportional to the number of cell divisions. This phenomenon can be detected and analyzed by flow cytometry under the excitation light of 488 nm, and can be used to detect the proliferation of cells .
102
Tacrolimus
Tacrolimus
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102 Cited Publications
製品番号: HY-13756
CAS 番号: 104987-11-3
純度:  99.93%
別名: FK506; Fujimycin; FR900506
Category:  

Infection Microorganisms Animals Macrolide Antibiotics Anti-inflammation/Immunoregulatory Antibiotics Disease Research Disease Research Fields Inflammation/Immunology

Target:  

Phosphatase FKBP Molecular Glues Bacterial Autophagy Antibiotic

Tacrolimus (FK506), a molecular glue, a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .
102
Tacrolimus monohydrate
Tacrolimus monohydrate
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102 Cited Publications
製品番号: HY-13756A
CAS 番号: 109581-93-3
純度:  99.67%
別名: FK506 monohydrate; Fujimycin monohydrate; FR900506 monohydrate
Category:  

Infection Microorganisms Macrolide Antibiotics Anti-inflammation/Immunoregulatory Antibiotics Disease Research Disease Research Fields Inflammation/Immunology

Target:  

Phosphatase FKBP Molecular Glues Bacterial Autophagy Antibiotic

Tacrolimus (FK506) monohydrate, a molecular glue, a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus monohydrate inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .
90
Nicotinamide
Nicotinamide
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90 Cited Publications
製品番号: HY-B0150
CAS 番号: 98-92-0
別名: Niacinamide; Nicotinic Acid amide
Category:  

Alkaloids Human Gut Microbiota Metabolites Microorganisms Neurological Disease Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer

Target:  

Environmental Pollutants Endogenous Metabolite Sirtuin HBV Organoid

Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD+, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity .
90
Nicotinamide (Standard)
Nicotinamide (Standard)
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90 Cited Publications
製品番号: HY-B0150R
CAS 番号: 98-92-0
別名: Niacinamide(Standard); Nicotinic Acid amide (Standard)
Target:  

Reference Standards Endogenous Metabolite Sirtuin

研究分野:  

Cancer

Nicotinamide (Standard) is the analytical standard of Nicotinamide. This product is intended for research and analytical applications. Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD+, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity .
77
Berberine sulfate
Berberine sulfate
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77 Cited Publications
製品番号: HY-N0716B
CAS 番号: 633-66-9
別名: Natural Yellow 18 sulfate
Category:  

Alkaloids Ranunculaceae Coptis chinensis Franch. Plants Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology

Target:  

Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Parasite Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB

Berberine sulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine sulfate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine sulfate has antineoplastic properties. The sulfate form improves bioavailability .
56
4-Hydroxytamoxifen
4-Hydroxytamoxifen
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56 Cited Publications
製品番号: HY-16950
CAS 番号: 68047-06-3
別名: (Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen; (Z)-Afimoxifene
Target:  

Estrogen Receptor/ERR

研究分野:  

Cancer

4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is an orally active, selective estrogen receptor modulator (SERM). 4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is also the active metabolic form of Tamoxifen (HY-13757A) in vivo and can be used to induce gene knockout in transgenic mice expressing CreER .
54
D-Glucose
D-Glucose
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54 Cited Publications
製品番号: HY-B0389
CAS 番号: 50-99-7
別名: Glucose; D-(+)-Glucose; Dextrose
Category:  

Metabolic Disease Endogenous metabolite Disease Research Fields Sweeteners Saccharides Food Research Monosaccharides

Target:  

Environmental Pollutants Endogenous Metabolite

D-Glucose is the naturally occurring form of glucose and the most abundant monosaccharide. D-Glucose is a critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic or abiotic stress response .
52
Berberine hemisulfate
Berberine hemisulfate
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52 Cited Publications
製品番号: HY-N0716A
CAS 番号: 316-41-6
別名: Natural Yellow 18 hemisulfate
Category:  

Infection Alkaloids Ranunculaceae Coptis chinensis Franch. Metabolic Disease Plants Disease Research Fields Isoquinoline Alkaloids Cancer

Target:  

Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB

Berberine hemisulfate is the hemisulfate form of Berberine (HY-N0716). Berberine hemisulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian. Berberine hemisulfate exhibits anti-inflammatory, antibiobic, antitumor, cardiovascular protective and neuroprotective activity .
51
Favipiravir
Favipiravir
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51 Cited Publications
製品番号: HY-14768
CAS 番号: 259793-96-9
純度:  99.97%
別名: T-705
Target:  

DNA/RNA Synthesis Influenza Virus SARS-CoV Bacterial

研究分野:  

Infection

Favipiravir (T-705) is a potent viral RNA polymerase inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC50 of 341 nM.
44
DL-Dithiothreitol
DL-Dithiothreitol
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44 Cited Publications
製品番号: HY-15917
CAS 番号: 3483-12-3
別名: DTT; rel-(2R,3R)-1,4-Dimercapto-2,3-butanediol
DL-Dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. When DL-Dithiothreitol is oxidized, it forms a stable six-membered ring with an internal disulfide bond .
43
ALC-0315
ALC-0315
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43 Cited Publications
製品番号: HY-138170
CAS 番号: 2036272-55-4
純度:  99.81%
ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .
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