SIRT1-IN-2
Based on 1 Customer Validation
SIRT1-IN-2 (compound 3h) is a potent and selective SIRT1 (silent information regulator 1) inhibitor, with an IC50 of 1.6 μM.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.31%
- CAS 番号: 2470969-89-0
- 分子式: C13H15ClN2O
- 分子量:250.72
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保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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SIRT1 1.6 μM (IC50) |
SIRT2 39 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
48 μM
Compound: 3h
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Cytotoxicity against human A549 cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell viability measured after 48 hrs by MTT assay
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[PMID: 32711231] |
| HCT-116 | IC50 |
37 μM
Compound: 3h
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Cytotoxicity against human HCT-116 cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as cell viability measured after 48 hrs by MTT assay
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[PMID: 32711231] |
| HEK-293T | IC50 |
>100 μM
Compound: 3h
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Cytotoxicity against human HEK293T cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HEK293T cells assessed as cell viability measured after 48 hrs by MTT assay
|
[PMID: 32711231] |
| HepG2 | IC50 |
40 μM
Compound: 3h
|
Cytotoxicity against human HepG2 cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as cell viability measured after 48 hrs by MTT assay
|
[PMID: 32711231] |
| HT-29 | IC50 |
>100 μM
Compound: 3h
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Cytotoxicity against human HT-29 cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as cell viability measured after 48 hrs by MTT assay
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[PMID: 32711231] |
| HUVEC | IC50 |
45 μM
Compound: 3h
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Cytotoxicity against human HUVEC cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HUVEC cells assessed as cell viability measured after 48 hrs by MTT assay
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[PMID: 32711231] |
| K562 | IC50 |
51 μM
Compound: 3h
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Cytotoxicity against human K562 cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human K562 cells assessed as cell viability measured after 48 hrs by MTT assay
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[PMID: 32711231] |
| MCF7 | IC50 |
48 μM
Compound: 3h
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Cytotoxicity against human MCF7 cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as cell viability measured after 48 hrs by MTT assay
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[PMID: 32711231] |
| NCI-H460 | IC50 |
>100 μM
Compound: 3h
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Cytotoxicity against human NCI-H460 cells assessed as cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells assessed as cell viability measured after 48 hrs by MTT assay
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[PMID: 32711231] |
SIRT1-IN-2 (compound 3h) (0-100 μM, 48 h) inhibits the proliferation of Human cancer cell lines including K562, HCT-116, HepG2, A549, and MCF-7, and shows significantly less cytotoxic on 293T cells and HUVEC[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human cancer cell lines (K562, HCT-116, H460, HepG2, A549, HT-29, MCF-7) and normal cell lines (293T, HUVEC). [1]
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Concentration:0, 0.01, 0.1, 1, 10, 100 μM
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Incubation Time:48 h
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Result:Inhibited the proliferation of Human cancer cell lines including K562, HCT-116, HepG2, A549, and MCF-7, with IC50 values of 51, 37, 40, 48, and 48 μM, respectively. And showed significantly less cytotoxic on 293T cells and HUVEC, with IC50 values of > 100 and 45 μM, respectively.
化学情報
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CAS 番号 2470969-89-0
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性状 Solid
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分子量 250.72
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分子式 C13H15ClN2O
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Color White to light yellow
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SMILES
CC(C1=C(NC2=CC=C(C=C21)Cl)CC(N)=O)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
DMSO : 100 mg/mL (398.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9885 mL | 19.9426 mL | 39.8851 mL | 99.7128 mL |
| 5 mM | 0.7977 mL | 3.9885 mL | 7.9770 mL | 19.9426 mL | |
| 10 mM | 0.3989 mL | 1.9943 mL | 3.9885 mL | 9.9713 mL | |
| 15 mM | 0.2659 mL | 1.3295 mL | 2.6590 mL | 6.6475 mL | |
| 20 mM | 0.1994 mL | 0.9971 mL | 1.9943 mL | 4.9856 mL | |
| 25 mM | 0.1595 mL | 0.7977 mL | 1.5954 mL | 3.9885 mL | |
| 30 mM | 0.1330 mL | 0.6648 mL | 1.3295 mL | 3.3238 mL | |
| 40 mM | 0.0997 mL | 0.4986 mL | 0.9971 mL | 2.4928 mL | |
| 50 mM | 0.0798 mL | 0.3989 mL | 0.7977 mL | 1.9943 mL | |
| 60 mM | 0.0665 mL | 0.3324 mL | 0.6648 mL | 1.6619 mL | |
| 80 mM | 0.0499 mL | 0.2493 mL | 0.4986 mL | 1.2464 mL | |
| 100 mM | 0.0399 mL | 0.1994 mL | 0.3989 mL | 0.9971 mL |
SIRT1-IN-2 関連分類
HY-146689 関連分類
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