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Cat. No.: HY-184351

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CP 132484

CP 132484 is a rat 5-HT_2A receptor agonist with a K_i of 1.1 nM and an IC₅₀ of 2.8 nM, and it exhibits over 40-fold selectivity over rat 5-HT1A receptors and bovine 5-HT1D receptors. CP 132484 stimulates phosphoinositide hydrolysis and intracellular calcium mobilization. CP 132484 can be used for research into diseases such as glaucoma.

For research use only. We do not sell to patients.

CAS No.: 143508-76-3
Formula: C₁₄H₁₈N₂O
Molecular Weight:230.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CP 132484 Chemical Structure

CAS No.: 143508-76-3

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target^[1]

5-HT_2A Receptor

1.1 nM (Ki)

5-HT_2A Receptor

2.8 nM (IC₅₀)

All 5-HT Receptor Isoforms :

In Vitro

CP 132484 (Compound 4a) (1 h) binds with high affinity to rat cortical 5-HT_2A receptors, with a K_i of 1.1 nM and an IC₅₀ of 2.8 nM^[1].
CP 132484 (1 h) potently stimulates phosphoinositide hydrolysis in A7r5 rat vascular smooth muscle cells via activation of the 5-HT_2A receptor, with an EC₅₀ of 213 nM and a potency reaching 96% relative to serotonin^[1].
CP 132484 stimulates calcium mobilization in A7r5 rat vascular smooth muscle cells by activating the 5-HT₂_a receptor, with an EC₅₀ of 95.5 nM and a potency equivalent to 70% of that of serotonin^[1].
CP 132484 (1 h) exhibits low affinity (IC₅₀ = 8410 nM) and no agonist activity at cloned human 5-HT_1A receptors expressed on CHO cell membranes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 143508-76-3
Molecular Weight 230.31
Formula C₁₄H₁₈N₂O
SMILES

O1C2=CC=C3C(C(=CN3C)CCN)=C2CCC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. May JA, et al. A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. J Med Chem. 2003 Sep 11;46(19):4188-95.
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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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CP 132484

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CP 132484 Related Classifications

HY-184351 Related Classifications