Bid - BH3 interacting domain death agonist Gene

Also Known as 2700049M22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12122

Summary

Enables ubiquitin protein Ligase binding activity. Involved in positive regulation of cellular component organization; protein-containing complex assembly; and release of cytochrome c from mitochondria. Acts upstream of or within several processes, including apoptotic signaling pathway; hepatocyte apoptotic process; and regulation of apoptotic process. Located in cytosol; membrane; and mitochondrion. Is integral component of mitochondrial membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human BID (BH3 interacting domain death agonist). [provided by Alliance of Genome Resources, Apr 2022]

Bid Products (1)

mRNA Protein Name
NM_007544.4 NP_031570.2 BH3-interacting domain death agonist

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
8918887 MGI
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
20392206 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
12011074 MGI
acts upstream of or within extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
10476969 MGI
acts upstream of or within hepatocyte apoptotic process IGI
IGI: Inferred from genetic interaction
20436477 MGI
acts upstream of or within mitochondrial ATP synthesis coupled electron transport IMP
IMP: Inferred from mutant phenotype
26219591 MGI
acts upstream of or within mitochondrial outer membrane permeabilization IGI
IGI: Inferred from genetic interaction
20436477 MGI
acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
26219591 MGI
acts upstream of or within positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
8918887 MGI
acts upstream of or within positive regulation of apoptotic signaling pathway IDA
IDA: Inferred from direct assay
8918887 MGI
acts upstream of or within positive regulation of fibroblast apoptotic process IDA
IDA: Inferred from direct assay
8918887 MGI
acts upstream of or within positive regulation of mitochondrial membrane potential IMP
IMP: Inferred from mutant phenotype
26219591 MGI
involved in positive regulation of protein-containing complex assembly IDA
IDA: Inferred from direct assay
20850011 MGI
involved in positive regulation of release of cytochrome c from mitochondria IGI
IGI: Inferred from genetic interaction
10950869 MGI
acts upstream of or within protein targeting to mitochondrion IMP
IMP: Inferred from mutant phenotype
11369777 MGI
involved in protein-containing complex assembly IDA
IDA: Inferred from direct assay
10950869 MGI
acts upstream of or within regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
15855651 MGI
acts upstream of or within regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
15855651 MGI
acts upstream of or within regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
8918887 MGI
acts upstream of or within regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
15855651 MGI
acts upstream of or within regulation of mitochondrial membrane permeability involved in apoptotic process IGI
IGI: Inferred from genetic interaction
14963330 MGI
involved in release of cytochrome c from mitochondria IDA
IDA: Inferred from direct assay
18084238 MGI
acts upstream of or within release of cytochrome c from mitochondria IMP
IMP: Inferred from mutant phenotype
11369777 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
8918887 MGI
located in membrane IDA
IDA: Inferred from direct assay
8918887 MGI
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
10950869 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
11369777 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

BH3-interacting domain death agonist

  • p22 BID

Bid Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Bid P70444 BAX Homo sapiens Q07812
Pull Down
26344567
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Bid Proteins

Cat. No. Product Name Accession Purity
HY-P72852 BID Protein, Mouse (His-GST) EDK99650.1 (M12-D206) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0493 Niflumic acid Inhibitor 99.61% Unkown
HY-B0493R Niflumic acid (Standard) Inhibitor 99.93% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-165550 Sphingosine / Phase 1

Pre-clinical Phase

Bioactive Molecules (26)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10510 BI-D1870 99.43% Unkown
HY-103661 BI-6C9 Inhibitor 98.47% Unkown
HY-N0559 Kirenol 99.82% Unkown
HY-108610A Edelfosine 99.0% Unkown
HY-N6005 Methyl caffeate 99.89% Unkown
HY-125305 Z-AEVD-FMK Inhibitor 95.0% Unkown
HY-18601 (±)-BI-D Inhibitor 98.06% Unkown
HY-167881 MLS-0053105 Inhibitor 98.89% Unkown
HY-121683 (E)-2-Hexadecenal 99.9% Unkown
HY-P5325A Bid BH3 (80-99) acetate 98.13% Unkown
HY-RS01502 BID Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-123244 YC137 / Unkown
HY-162642 Bfl-1-IN-3 Inhibitor / Unkown
HY-N0559R Kirenol (Standard) / Unkown
HY-N17676 3-Tridecylphenol / Unkown
HY-N7917 Tenacigenoside A / Unkown
HY-N8617 Trijuganone C / Unkown
HY-P10614 Bid BH3 peptide Inducer / Unkown
HY-P10614A Bid BH3 peptide acetate Inducer 98.13% Unkown
HY-P11374 Bid BH3-Gly-r8 Ligand / Unkown
HY-P5325 Bid BH3 (80-99) / Unkown
HY-P5325F Bid BH3 (80-99), FAM labeled / Unkown
HY-P5327 r8 Bid BH3 / Unkown
HY-183402 FLLL12 / Unkown
HY-RS16655 Bid Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23090 Bid Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bid NCBI NCBI:637