AVP - arginine vasopressin Gene

Also Known as VP; ADH; ARVP; AVRP; AVP-NPII

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 551

About AVP

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,082,556-3,084,724 (from NCBI)

This gene has 1 transcript (splice variant), 297 orthologues, 1 paralogue and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the vasopressin/oxytocin family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the neuropeptide hormone arginine vasopressin, and two Other peptides, neurophysin 2 and copeptin. Arginine vasopressin is a posterior pituitary hormone that is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI). This gene is present in a gene cluster with the related gene oxytocin on chromosome 20. [provided by RefSeq, Nov 2015]

AVP Products (1)

mRNA	Protein	Name
NM_000490.5	NP_000481.2	vasopressin-neurophysin 2-copeptin preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables V1A vasopressin receptor binding	IPI IPI: Inferred from physical interaction	18402937	GOA
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IDA IDA: Inferred from direct assay	18402937	GOA
enables neuropeptide hormone activity	IDA IDA: Inferred from direct assay	18402937	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	18402937	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	18402937	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	18402937	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	18538351	GOA
involved in symbiont entry into host cell	IDA IDA: Inferred from direct assay	33713620	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular region	IDA IDA: Inferred from direct assay	33713620	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AVP Protein Structure

Hormone_4

Hormone_5

0
100
164 a.a.

Protein Preferred Names	Protein Names
vasopressin-neurophysin 2-copeptin	antidiuretic hormone

Related Diseases

Diseases	Alias
Diabetes Insipidus, Neurohypophyseal	Neurohypophyseal Diabetes Insipidus Cdi Pituitary Diabetes Insipidus Vasopressin Defective Diabetes Insipidus Vasopressin Deficiency Central Diabetes Insipidus Diabetes Insipidus, Neurogenic Diabetes Insipidus, Primary Central Diabetes Insipidus, Cranial Type Diabetes Insipidus Secondary To Vasopressin Deficiency Diabetes Insipidus, Central Diabetes Insipidus, Pituitary NDI Diabetes Insipidus Cranial Type Neurogenic Diabetes Insipidus Primary Central Diabetes Insipidus
Hereditary Central Diabetes Insipidus	Hereditary Cdi Hereditary Neurogenic Diabetes Insipidus
Diabetes Insipidus
Central Diabetes Insipidus	Neurogenic Diabetes Insipidus Diabetes Insipidus Cranial Type Diabetes Insipidus Neurogenic Diabetes Insipidus Neurohypophyseal Neurohypophyseal Diabetes Insipidus Pituitary Diabetes Insipidus Cdi Doid:0081055 Diabetes Insipidus Di - [Diabetes Insipidus] Adh - [Antidiuretic Hormone Secretion] Deficiency Diabetes Mellitus Insipidus Familial Diabetes Insipidus Antidiuretic Hormone Hyposecretion Vasopressin Deficiency Syndrome Primary Central Diabetes Insipidus Vasopressin Deficiency Vasopressin Hyposecretion Diabetes Insipidus Secondary To Vasopressin Deficiency
Inappropriate Adh Syndrome	Syndrome Of Inappropriate Antidiuretic Hormone Secretion Syndrome Of Inappropriate Secretion Of Antidiuretic Hormone Siadh Syndrome Of Inappropriate Vasopressin Secretion Syndrome Of Inappropriate Secretion Of Adh Inappropriate Secretion Of Antidiuretic Hormone Syndrome Of Inappropriate Antidiuresis Siadh - [Syndrome Of Inappropriate Secretion Of Antidiuretic Hormone] Antidiuretic Hormone Syndrome Hormone Secretion Inadequate Antidiuretic Hormone Secretion Syndrome Schwartz-Bartter Syndrome Siad - [Syndrome Of Inappropriate Antidiuresis] Hypersecretion Of Antidiuretic Hormone
Nephrogenic Diabetes Insipidus	Vasopressin-Resistant Diabetes Insipidus Diabetes Insipidus, Nephrogenic Diabetes Insipidus Nephrogenic Congenital Nephrogenic Diabetes Insipidus Adh Resistant Diabetes Insipidus Diabetes Insipidus Nephrogenic X-Linked Diabetes Insipidus Nephrogenic Type 1 Adh-Resistant Diabetes Insipidus Diabetes Insipidus Renalis Ndi Renal Diabetes Insipidus Familial Nephrogenic Diabetes Antidiuretic-Hormone-Resistant Diabetes Insipidus Adiuretin-Resistant Diabetes Insipidus Ndi - [Nephrogenic Diabetes Insipidus] Diabetes Tenuifluus Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus Hereditary Nephrogenic Diabetes Insipidus Familial Nephrogenic Diabetes Insipidus Primary Nephrogenic Diabetes Insipidus
Pituitary Apoplexy	Pituitary Tumor Apoplexy
Gestational Diabetes Insipidus	Transient Diabetes Insipidus Of Pregnancy Diabetes Insipidus Gestational Gestagenic Diabetes Insipidus Doid:0081057
Dipsogenic Diabetes Insipidus	Primary Polydipsia Doid:0081058 Psychogenic Polydipsia
Myxedema
Central Pontine Myelinolysis	Myelinolysis, Central Pontine Osmotic Demyelination Syndrome Cpm Myelinolysis Central Pontine Central Pontine Myelinosis
Lung Oat Cell Carcinoma	Oat Cell Carcinoma Carcinoma Oat Cell Carcinoma, Small Cell
Space Motion Sickness
Nephrogenic Syndrome Of Inappropriate Antidiuresis	NSIAD
Tuberculous Encephalopathy
Pituitary Hormone Deficiency, Combined, 2	Panhypopituitarism Combined Pituitary Hormone Deficiency CPHD2 Ateliotic Dwarfism With Hypogonadism Pituitary Dwarfism Iii Hanhart Dwarfism Simmond'S Disease Simmonds' Disease Cphd Pituitary Hormone Deficiency, Combined Hormone Deficiency, Pituitary, Combined, Type 2 Pituitary Dwarfism Type 3 Sheehan Syndrome
Pituitary Infarct	Pituitary Infarction
X-Linked Nephrogenic Diabetes Insipidus	Nephrogenic Diabetes Insipidus Type 1 Doid:0081060
Pneumonia	Acute Pneumonia Pneumonias Infectious Pneumonia Pn - [Pneumonia] Lobar Pneumonia Nos Multifocal Pneumonia Orthostatic Pneumonia Pneumonia Nos Chronic Pneumonia Nos Atypical Pneumonia Passive Pneumonia Purulent Pneumonia Interstitial Lobar Pneumonia Pneumonia, Unspecified Pneumonia Due To Chlamydia Pneumonia Due To Chlamydia Pneumoniae Pneumonia Due To E. Coli Escherichia Coli Lobar Pneumonia Pneumonia Due To H. Influenzae Pneumonia Due To Hemophilus Influenzae Bronchopneumonia Due To H. Influenzae Haemophilus Influenzae Lobar Pneumonia Bronchopneumonia Due To Hemophilus Influenzae Pseudomonal Pneumonia Pseudomonas Pneumonia Pseudomonas Lobar Pneumonia Staphylococcal Pneumonia Staphylococcus Pneumonia Acute Staphylococcal Pneumonia Staphylococcal Double Pneumonia Staphylococcal Lobar Pneumonia Staphylococcal Purulent Pneumonia Staphylococcal Bronchopneumonia Pneumococcal Pneumonia Pneumococcus Pneumonia Bronchopneumonia Due To S. Pneumoniae Pneumococcal Lobar Pneumonia Streptococcal Pneumoniae Pneumonia Streptococcus Pneumoniae Lobar Pneumonia Pyemic Pneumococcal Embolism With Pneumonia Bronchopneumonia Due To Streptococcus Pneumoniae Pneumonia Due To Streptococcus, Group B Group B Streptococcal Pneumonia Adenovirus Pneumonia Adenoviral Pneumonia Adenovirus Viral Pneumonia Pneumonia Respiratory Syncytial Viral Parainfluenza Viral Pneumonia Parainfluenzal Pneumonia Parainfluenza Virus Pneumonia Human Metapneumovirus Pneumonia Human Metapneumovirus Infection Resulting In Pneumonia Pneumocystis Pneumonia Plasma Cells Pneumonia
Fanconi Syndrome	Infantile Nephropathic Cystinosis Adult Fanconi Syndrome Congenital Fanconi Syndrome De Toni-Fanconi Syndrome Fanconi-De Toni Syndrome Lignac-Fanconi Syndrome Fanconi Renotubular Syndrome Primary Fanconi Renotubular Syndrome De Toni-Debre-Fanconi Syndrome Adult Fanconi Anemia Detoni Fanconi Syndrome Fanconi-De-Toni Syndrome Primary Fanconi Syndrome Detoni-Debre-Fanconi Syndrome Primary Fanconi Renal Syndrome Fanconi Anemia Cystinosis, Infantile Nephropathic Fanconi-Bickel Syndrome Renal Fanconi Syndrome Lowe-Bickel Syndrome
Liver Cirrhosis	Cirrhosis Cirrhosis Of Liver CIRRH Cryptogenic Cirrhosis Cirrhosis, Cryptogenic Cirrhosis Nos
Suprasellar Meningioma
Developmental And Epileptic Encephalopathy 38	DEE38 Epileptic Encephalopathy, Early Infantile, 38 Eiee38 Developmental And Epileptic Encephalopathy, 38 Glycosylphosphatidylinositol Biosynthesis Defect 23 Gpibd23 Early Infantile Epileptic Encephalopathy 38
Sheehan Syndrome	Postpartum Hypopituitarism Sheehan'S Syndrome Postpartum Panhypopituitarism Postpartum Panhypopituitary Syndrome Postpartum Pituitary Necrosis Simmond'S Disease
Pituitary Gland Disease	Pituitary Diseases Pituitary Dysfunction Pituitary Disease Pituitary Deficiency Pituitary Disorders
Pulmonary Embolism	Pulmonary Artery Embolism Pulmonary Embolus Pulmonary Emboli
Coronary Stenosis	Coronary Artery Stenosis
Tuberculous Epididymitis	Tuberculosis Of Epididymis
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Malignant Olfactory Nerve Neoplasm	Malignant Olfactory Nerve Tumor Malignant Tumor Of Olfactory Nerve Primary Malignant Neoplasm Of Olfactory Nerve
Nasal Cavity Benign Neoplasm	Benign Nasal Cavity Neoplasm Neoplasm Of Nasal Cavity Tumor Of The Nasal Cavity Cancer Of Nasal Cavity Nostril Cancer Primary Malignant Neoplasm Of Nasal Cavity Primary Malignant Neoplasm Of Vestibule Of Nose
Hypothalamic Disease	Hypothalamic Diseases Hypothalamic Dysfunction Hypothalamic Disorder Hypothalamic Dysfunction Syndromes
Haemophilus Meningitis	Meningitis, Haemophilus
Alcoholic Cardiomyopathy	Cardiomyopathy, Alcoholic Alcohol-Induced Heart Muscle Disease Dilated Cardiomyopathy Secondary To Alcohol
Paralytic Ileus	Adynamic Ileus Paralytic Ileus Of Bowel Ileus Nos Paralysis Of Bowel Paralysis Of Intestine Adynamic Intestinal Obstruction Paralytic Intestinal Ileus
Cranial Nerve Malignant Neoplasm	Cranial Nerve Neoplasms Malignant Neoplasm Of Cranial Nerve Malignant Tumor Of Cranial Nerve Malignant Tumor Of The Cranial Nerve
Porphyria, Acute Intermittent	Acute Intermittent Porphyria Porphobilinogen Deaminase Deficiency Pbgd Deficiency AIP Porphyria, Swedish Type Uroporphyrinogen Synthase Deficiency Ups Deficiency Porphyria, Acute Intermittent, Nonerythroid Variant Hydroxymethylbilane Synthase Deficiency Aip - Acute Intermittent Porphyria Porphyria Intermittent Acute Pyrroloporphyria Hmbs Deficiency Porphyria Acute Intermittent
Bronchus Cancer	Malignant Neoplasm Of Bronchus And Lung Bronchus Carcinoma Bronchogenic Carcinoma Malignant Neoplasm Of Bronchus Or Lung Bc - Bronchogenic Carcinoma Carcinoma, Bronchogenic Bronchial Neoplasms
Sphenoid Sinusitis	Sphenoidal Sinusitis
Gaba Aminotransferase Deficiency	Gamma-Aminobutyric Acid Transaminase Deficiency Gamma Aminobutyric Acid Transaminase Deficiency Gaba Transaminase Deficiency Gamma-Amino Butyric Acid Transaminase Deficiency 4 Alpha Aminobutyrate Transaminase Deficiency Abat Gabat Gamma Aminobutyrate Transaminase Deficiency
Alcohol-Related Birth Defects	Arbd Alcohol-Related Birth Defect Alcohol Related Birth Defect Fetal Alcohol Syndrome
Fourth Cranial Nerve Palsy	Fourth Nerve Palsy Fourth Cranial Nerve Paresis Fourth Or Trochlear Nerve Palsy 4th Nerve Palsy Fourth Cranial Nerve Paralysis Superior Oblique Palsy Trochlear Nerve Palsy Trochlear Nerve Paralysis Trochlear Nerve Weakness Isolated Trochlear Nerve Palsy Atrophy Of Fourth Cranial Nerve Atrophy Of Trochlear Nerve
Small Cell Cancer Of The Lung	Small Cell Lung Cancer Small Cell Lung Carcinoma Sclc Small-Cell Cancer Of Lung Lung Small Cell Carcinoma Sclc1 Sccl Cancer, Lung, Small Cell Small Cell Carcinoma Of Lung Carcinoma, Small Cell
Hepatorenal Syndrome	Hepato-Renal Syndrome Hepatorenal Failure Hrf - [Hepatorenal Failure] Hepatorenal Degeneration Hepatic Renal Syndrome Hepatic Renal Failure Renal Hepatic Failure Urohepatic Syndrome
Cranial Nerve Palsy	Cranial Nerve Paralysis Cranial Nerve Diseases Cranial Nerve Palsies
Olfactory Neuroblastoma	Esthesioneuroblastoma Asthesioneuroblastoma Esthesioneuroepithelioma Olfactory Esthesioneuroblastoma Paranasal Sinus Olfactory Neuroblastoma Esthesioneuroblastoma, Olfactory Esthesioneuroblastoma Of Nasal Cavity
Hypertensive Encephalopathy	Encephalopathy, Hypertensive
Post-Cardiac Arrest Syndrome	Post Cardiac Syndrome
Bartter Disease	Bartter Syndrome Bartter'S Syndrome Aldosteronism With Hyperplasia Of The Adrenal Cortex Hypokalemic Alkalosis With Hypercalciuria Potassium Wasting Juxtaglomerular Hyperplasia With Secondary Aldosteronism Renal Tubular Normotensive Hypokalemic Alkalosis With Hypercalciuria Salt-Losing Tubular Disorder, Henle'S Loop Type Salt-Wasting Tubulopathy, Henle'S Loop Type Bartters Syndrome
Restless Legs Syndrome	Wed Willis-Ekbom Disease Restless Leg Syndrome Ekbom Syndrome Wittmaack-Ekbom Syndrome Willis Ekbom Disease Ekbom'S Syndrome Rls Restless Legs Restless Legs Syndrome, Susceptibility To
Conn'S Syndrome	Cushing Syndrome Hyperaldosteronism Primary Hyperaldosteronism Hypercortisolism Primary Aldosteronism Cushing'S Syndrome Adrenal Gland Hyperfunction Conn Syndrome Hyperadrenalism Ectopic Acth Syndrome Hyperadrenocorticism Cushing Disease Cushing'S Disease Adrenal Cortex Adenoma Corticotroph Pituitary Adenoma Pituitary Corticotroph Micro-Adenoma Pituitary-Dependent Cushing Syndrome Pituitary Acth Hypersecretion Acth Syndrome, Ectopic Acth-Secreting Pituitary Adenoma Adrenal Hyperfunction Resulting From Pituitary Acth Excess Ectopic Adrenocorticotropic Hormone Syndrome Nodular Primary Adrenocortical Dysplasia Pituitary Dependent Cushing Syndrome Pituitary Cushing Syndrome Pituitary-Dependant Cushing Syndrome Pituitary-Dependant Hypercortisolism Pituitary-Dependant Hypercortisolism Disorder Aldosteronism Primary Acth Syndrome Ectopic Adrenal Cushing'S Syndrome Adrenal Cortical Adenoma Cushing Syndrome Nos Cortisol Hypersecretion Corticoadrenal Hypersecretion Cushing Syndrome Secondary To Ectopic Acth-Secretion Ectopic Cushing Syndrome Hypercortisolism Due To Nonpituitary Tumour Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome Idiopathic Aldosteronism Aldosteronism Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia Primary Aldosteronism Due To Adrenal Hyperplasia
Fetal Alcohol Spectrum Disorder	Fetal Alcohol Spectrum Disorders Fetal Alcohol Syndrome
Fetal Alcohol Syndrome	Fetal Alcohol Spectrum Disorders Arbd Arnd Alcohol-Related Birth Defects Alcohol-Related Neurodevelopmental Disorder Fas Fasd Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta Or Breast Milk Alcohol Related Birth Defect Alcohol Related Neurodevelopmental Disorder Alcohol Affecting Fetus Or Newborn Via Placenta Or Breast Milk Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta And/Or Breast Milk Dysmorphism Due To Alcohol Fetal Etoh Syndrome
Substance Dependence
Intracranial Hypertension	Raised Intracranial Pressure
Septooptic Dysplasia	Septo-Optic Dysplasia De Morsier Syndrome Growth Hormone Deficiency With Pituitary Anomalies SOD Pituitary Hormone Deficiency, Combined, 5 Septo-Optic Dysplasia Spectrum Septo-Optic Dysplasia With Growth Hormone Deficiency Pituitary Hormone Deficiency, Combined 5 Hypopituitarism And Septooptic 'Dysplasia' GHDPA CPHD5 Dysplasia, Septo-Optic Kallmann Syndrome
Peripheral Vertigo	Vertigo, Peripheral
Optic Nerve Hypoplasia, Bilateral	Optic Nerve Hypoplasia Bilateral Optic Nerve Hypoplasia Optic Nerve Hypoplasia, Familial Bilateral Familial Bilateral Optic Nerve Hypoplasia Isolated Optic Nerve Hypoplasia/Aplasia Optic Nerve Aplasia, Bilateral Onh BONH Bilateral Optic Nerve Aplasia Hypoplasia, Optic Nerve, Bilateral
Mineral Metabolism Disease	Mineral Metabolism Disorder Disorder Of Mineral Metabolism
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Alcohol Use Disorder	Alcohol Abuse Alcoholism Ethanol Abuse Alcohol Addiction Alcohol Dependence Alcoholic Intoxication, Chronic Alcohol-Related Disorders
Hypokalemia	Potassium Deficiency Potassium Deficiency Disorder Hypopotassemia Potassium Potassium [K] Deficiency Hypokalaemic Syndrome Hypopotassaemia Hypopotassaemia Syndrome Hypokalaemic Potassium Depletion
Sudden Infant Death Syndrome	SIDS Sudden Infant Death Syndrome, Susceptibility To Cot Death Crib Death Sudden Death Of Nonspecific Cause In Infancy Sudden Infant Death Death, Sudden, Syndrome, Infant
Variegate Porphyria	Porphyria Variegata Protoporphyrinogen Oxidase Deficiency VP Ppox Deficiency Porphyria, South African Type Porphyria Variegata, Susceptibility To Protocoproporphyria Porphyria Variegate Porphyria South African Type Pv Porphyria, Variegate Vp - [Variegate Porphyria]
Renal Tubular Transport Disease	Renal Tubular Transport, Inborn Errors Inborn Renal Tubular Transport Disorder
Autosomal Dominant Polycystic Kidney Disease	Polycystic Kidney Disease, Adult Type Adpkd Polycystic Kidney Diseases Polycystic Kidney, Autosomal Dominant Congenital Biliary Ectasias Polycystic Kidney And Hepatic Disease 1 Polycystic Kidney Disease, Autosomal Dominant Kidney, Polycystic, Disease, Autosomal Dominant Adult Polycystic Kidney Disease Polycystic Kidney, Adult Type Apckd - [Autosomal Polycystic Kidney Disease]
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Analbuminemia	ANALBA Congenital Analbuminemia Hypoalbuminemia
Intracranial Berry Aneurysm	Familial Aneurysmal Subarachnoid Hemorrhage Familial Berry Aneurysm Familial Intracranial Saccular Aneurysm Saccular Cerebral Aneurysm Aneurysm, Intracranial Berry Aneurysmal Subarachnoid Hemorrhage Aneurysm, Intracranial Berry, 1
Adrenal Gland Disease	Adrenal Gland Diseases Adrenal Gland Disorders
Neurogenic Bladder	Neurogenic Dysfunction Of The Urinary Bladder Neurogenic Urinary Bladder Disorder Neuropathic Bladder Bladder Neurogenic Urinary Bladder, Neurogenic Neurogenic Urinary Bladder
Substance Abuse	Substance-Related Disorders Substance Abuse Problem
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Cystic Kidney Disease	Renal Cyst Simple Renal Cyst Kidney Cysts Kidney Diseases, Cystic Renal Cysts Kidney Cyst Cystic Kidney Congenital Cystic Kidney Disease Cystic Kidney Diseases Bosniak 1 Cyst
Endometrial Small Cell Carcinoma
Diabetes Mellitus	Diabetes
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Alcohol Dependence, Protection Against Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Supine Hypotensive Syndrome	Maternal Hypotension Syndrome Antepartum Maternal Hypotension Syndrome Postpartum Maternal Hypotension Syndrome Maternal Hypotension Syndrome, Antepartum Condition Or Complication Maternal Hypotension Syndrome, Postpartum Condition Or Complication Maternal Hypotension Syndrome, Unspecified Trimester
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17000	Tolvaptan		99.95%	Yes
HY-B1811	Vasopressin		99.65%	Yes
HY-P0049	Argipressin	Agonist	98.71%	Unkown
HY-18346	Mozavaptan	Antagonist	99.71%	Unkown
HY-123593	Mozavaptan hydrochloride	Antagonist	99.80%	Unkown
HY-P0049A	Argipressin diacetate		/	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10066	Nelivaptan	Antagonist	99.89%	Phase 2
HY-133173	Niravoline	Agonist	/	Phase 2
HY-19070	BRL-52656	Agonist	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (28)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103023	CLP290	Activator	99.96%	Unkown
HY-P1390	d[Cha4]-AVP	Agonist	98.81%	Unkown
HY-W539944	Argipressin acetate		99.16%	Unkown
HY-RS09357	NLRP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-103703	DEAE Cross-linked dextran A 25		/	Unkown
HY-134454A	Z-Pro-prolinal	Inhibitor	99.9%	Unkown
HY-157220	Tolvaptan phosphate ester sodium	Antagonist	99.85%	Unkown
HY-P3066	SKF 100398		99.48%	Unkown
HY-P4990	Pro8-Oxytocin	Activator	99.68%	Unkown
HY-P4990A	Pro8-Oxytocin TFA	Activator	99.68%	Unkown
HY-RS06579	IFNAR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-118768	FMS586 free base		/	Unkown
HY-165484	AVP-13358	Inhibitor	/	Unkown
HY-18346S	Mozavaptan-d6	Antagonist	/	Unkown
HY-P10046	[Deamino-Pen1,Val4,D-Arg8]-vasopressin	Inhibitor	/	Unkown
HY-P1390A	d[Cha4]-AVP TFA	Agonist	/	Unkown
HY-P1747	Pneumadin, rat		/	Unkown
HY-P4010	Desamino(D-3-(3′-pyridyl)-Ala2,Arg8)-Vasopressin	Agonist	/	Unkown
HY-P5007	Copeptin (human)		/	Unkown
HY-RS01280	AVP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W583271	Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol	Inhibitor	/	Unkown
HY-111291	ICI 169369 free base	Inhibitor	/	Unkown
HY-118918	YM218 free base	Antagonist	/	Unkown
HY-129333	L-364918	Antagonist	/	Unkown
HY-17000S	Tolvaptan-d7		/	Unkown
HY-P5006	(d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin	Antagonist	/	Unkown
HY-RS16746	Avp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23183	Avp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	AVP	VGNC	VGNC:26356
Rattus norvegicus	AVP	RGD	RGD:2184
Felis catus	AVP	VGNC	VGNC:98511
Mus musculus	AVP	MGD	MGI:88121
Macaca mulatta	AVP	VGNC	VGNC:107771
Canis familiaris	AVP	VGNC	VGNC:38317
Others	AVP	NCBI