L-364918
L-364918 is a potent and selective oxytocin and arginine vasopressin antagonist with Ki values of 30, 1300, 2400 nM for OT, AVP-V1, AVP-V2, respectively. L-364918 has the potential for the research of preterm labor and disturbances in water balance.
For research use only. We do not sell to patients.
- CAS No.: 122211-31-8
- Formula: C40H54N8O6
- Molecular Weight:742.91
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Vasopressin Receptor Isoforms
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Biological Activity
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V2 Receptor 2400 nM (Ki) |
V1 receptor 1300 nM (Ki) |
oxytocin 30 nM (Ki) |
L-364918 (0-1 mM) inhibits AVP-stimulated accumulation of inositol phosphates dose-dependently in hepatocytes prelabeled with inositol with an IC50 value 0f 8.6 µM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 122211-31-8
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Molecular Weight 742.91
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Formula C40H54N8O6
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SMILES
O=C1NC(C(CC)C)C(N2NCCCC2C(N3NCCCC3C(N(C(CC4=CC=CC=C4)C(N5CCCC5C(NC1CC6=CC=CC=C6)=O)=O)C)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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