BRL-52656
BRL-52656 is a blood-brain barrier (BBB)-penetrable KOR receptor agonist that exhibits a biphasic effect. At low doses, BRL-52656 decreases blood pressure, whereas high doses have the opposite effect in spontaneously hypertensive rats. Additionally, BRL-52656 induces water diuresis by inhibiting the secretion of vasopressin (AVP).
For research use only. We do not sell to patients.
- CAS No.: 115642-84-7
- Formula: C19H26ClF3N2O
- Molecular Weight:390.87
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Opioid Receptor Isoforms
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Biological Activity
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κ Opioid Receptor/KOR |
Chemical Information
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CAS No. 115642-84-7
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Molecular Weight 390.87
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Formula C19H26ClF3N2O
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SMILES
FC(F)(F)C(C=C1)=CC=C1CC(N(CCCC2)[C@@H]2CN3CCCC3)=O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Brooks DP, et al. Opiate receptors within the blood-brain barrier mediate kappa agonist-induced water diuresis. J Pharmacol Exp Ther. 1993 Jul;266(1):164-71. [Content Brief]
[2]. Sako MO, et al. Filtering the Signal: Kappa Opioid Receptors in the Kidney. Function (Oxf). 2025 Sep 15;6(5):zqaf042. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BRL-52656 Related Classifications
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