115642-84-7
Chemical Structure
BRL-52656
- CAS No.: 115642-84-7
- Formula:C19H26ClF3N2O
- Molecular Weight:390.87
IUPAC Name: (S)-1-(2-(pyrrolidin-1-ylmethyl)piperidin-1-yl)-2-(4-(trifluoromethyl)phenyl)ethan-1-one hydrochloride
InChIKey: RPYYEZAVUKVVFN-LMOVPXPDSA-N
SMILES: FC(F)(F)C(C=C1)=CC=C1CC(N(CCCC2)[C@@H]2CN3CCCC3)=O.Cl
Biological Activity: BRL-52656 is a blood-brain barrier (BBB)-penetrable KOR receptor agonist that exhibits a biphasic effect. At low doses, BRL-52656 decreases blood pressure, whereas high doses have the opposite effect in spontaneously hypertensive rats. Additionally, BRL-52656 induces water diuresis by inhibiting the secretion of vasopressin (AVP)[1][2].
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BRL-52656 | BRL-52656 is a blood-brain barrier (BBB)-penetrable KOR receptor agonist that exhibits a biphasic effect. At low doses, BRL-52656 decreases blood pressure, whereas high doses have the opposite effect in spontaneously hypertensive rats. Additionally, BRL-52656 induces water diuresis by inhibiting the secretion of vasopressin (AVP). | |||||||||||||||||||||
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- [1]. Brooks DP, et al. Opiate receptors within the blood-brain barrier mediate kappa agonist-induced water diuresis. J Pharmacol Exp Ther. 1993 Jul;266(1):164-71. [Content Brief]
- [2]. Sako MO, et al. Filtering the Signal: Kappa Opioid Receptors in the Kidney. Function (Oxf). 2025 Sep 15;6(5):zqaf042. [Content Brief]
Keywords
