105 Results for "

African

" in MedChemExpress (MCE) Product Catalog:
Products (105)

105 Results for "African" in MCE Product Catalog:

27
GS-441524
GS-441524
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27 Publications Verification
Cat. No.: HY-103586
CAS No.: 1191237-69-0
Purity:  99.89%
Target:  

DNA/RNA Synthesis SARS-CoV

Research Areas:  

Infection

GS-441524 is a potent, orally active and CNS-penetrant viral RNA-dependent RNA polymerase inhibitor. GS-441524 competes with natural nucleosides to block viral RNA transcription as an alternative substrate and RNA chain terminator. GS-441524 inhibits the replication of feline infectious peritonitis virus, African swine fever virus, and severe acute respiratory syndrome coronavirus 2. GS-441524 reduces viral RNA levels in cats. GS-441524 can be used in research related to feline infectious peritonitis, African swine fever, and coronavirus disease 2019 (COVID-19) .
27
GS-441524 hydrochloride
GS-441524 hydrochloride
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27 Publications Verification
Cat. No.: HY-103586A
CAS No.: 2378280-82-9
Target:  

DNA/RNA Synthesis SARS-CoV

Research Areas:  

Infection

GS-441524 hydrochloride is a potent, orally active and CNS-penetrant viral RNA-dependent RNA polymerase inhibitor. GS-441524 hydrochloride competes with natural nucleosides to block viral RNA transcription as an alternative substrate and RNA chain terminator. GS-441524 hydrochloride inhibits the replication of feline infectious peritonitis virus, African swine fever virus, and severe acute respiratory syndrome coronavirus 2. GS-441524 hydrochloride reduces viral RNA levels in cats. GS-441524 hydrochloride can be used in research related to feline infectious peritonitis, African swine fever, and coronavirus disease 2019 (COVID-19) .
22
Eflornithine
Eflornithine
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22 Cited Publications
Cat. No.: HY-B0744
CAS No.: 70052-12-9
Synonyms: DFMO; MDL71782; RMI71782; α-difluoromethylornithine
Target:  

Parasite

Research Areas:  

Infection Cancer

Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.
22
Eflornithine hydrochloride hydrate
Eflornithine hydrochloride hydrate
0 Images
22 Cited Publications
Cat. No.: HY-B0744B
CAS No.: 96020-91-6
Synonyms: DFMO hydrochloride hydrate; MDL-71782 hydrochloride hydrate; RMI-71782 hydrochloride hydrate; α-difluoromethylornithine hydrochloride hydrate
Target:  

Parasite

Research Areas:  

Cancer

Eflornithine hydrochloride hydrate (DFMO hydrochloride hydrate) is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine hydrochloride hydrate is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women .
22
Eflornithine hydrochloride
Eflornithine hydrochloride
0 Images
22 Cited Publications
Cat. No.: HY-B0744A
CAS No.: 68278-23-9
Synonyms: DFMO hydrochloride; MDL71782 hydrochloride; RMI71782 hydrochloride; α-difluoromethylornithine hydrochloride
Target:  

Parasite

Research Areas:  

Infection Cancer

Eflornithine hydrochloride is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.
9
Digitoxin
Digitoxin
0 Images
9 Cited Publications
Cat. No.: HY-B1357
CAS No.: 71-63-6
Category:  

Cardiovascular Disease Digitalis purpurea Linn. Scrophulariaceae Plants Disease Research Fields Steroids

Target:  

Environmental Pollutants Apoptosis Na+/K+ ATPase Bcl-2 Family Caspase HSV Calcium Channel

Digitoxin is an anti-cancer agent. Digitoxin induces apoptosis, inhibits influenza cytokine storm, causes DNA double-stranded breaks (DSBs) and blocks the cell cycle at the G2/M phase. Digitoxin induces calcium uptake into cells by forming transmembrane calcium channels and can be used for research of heart failure .
3
Acoziborole
Acoziborole
0 Images
3 Cited Publications
Cat. No.: HY-19910
CAS No.: 1266084-51-8
Synonyms: SCYX-7158; AN5568
Target:  

Parasite

Research Areas:  

Infection

Acoziborole (SCYX-7158) is an effective, safe and orally active antiprotozoal agent for the research of human african trypanosomiasis (HAT). In the T. b. brucei S427 strain, the MIC value for SCYX-7158 is 0.6 μg/mL .
2
Tryptophol
Tryptophol
0 Images
2 Cited Publications
Cat. No.: HY-W010155
CAS No.: 526-55-6
Synonyms: Indole-3-ethanol
Category:  

Human Gut Microbiota Metabolites Natural Products Microorganisms Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Apoptosis Caspase Bacterial

Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces apoptosis and cleavage of caspase-8. Tryptophol inhibits Cunninghamella blakesleeana biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy .
1
Cholesteryl oleate
Cholesteryl oleate
0 Images
1 Cited Publications
Cat. No.: HY-113217
CAS No.: 303-43-5
Purity:  ≥99.0%
Category:  

Other Diseases Endogenous metabolite Disease Research Fields Steroids

Target:  

Liposome Endogenous Metabolite

Cholesteryl oleate is an ester compound formed from Cholesterol (HY-N0322) and Oleic acid (HY-N1446), which is involved in lipid transport, storage and cell membrane formation in living organisms. Cholesteryl oleate may serve as a potential biomarker for prostate cancer. Cholesteryl oleate can also prepare cationic solid lipid nanoparticles (SLNs) for efficient gene silencing .
1
DDD85646
DDD85646
0 Images
1 Cited Publications
Cat. No.: HY-103056
CAS No.: 1215010-55-1
Purity:  99.72%
Synonyms: IMP-366
Target:  

DNA/RNA Synthesis Parasite

Research Areas:  

Infection

DDD85646 (IMP-366) is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC50=2 nM; hNMT IC50=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis .
1
Quercetagitrin
Quercetagitrin
0 Images
1 Cited Publications
Cat. No.: HY-N4150
CAS No.: 548-75-4
Synonyms: Quercetagetin-7-O-glucoside
Category:  

Flavonols Flavonoids Erythrina melanacantha Taub. ex Harms Phenols Polyphenols Plants Compositae Disease Research Fields Inflammation/Immunology

Target:  

Phosphatase Tau Protein NF-κB

Quercetagitrin (Quercetagetin-7-O-glucoside) is a natural product that can be isolated from the African marigold (Tagetes erecta). Quercetagitrin has anti-inflammatory activity. Quercetagitrin inhibits Tau accumulation. Quercetagitrin can reverse neuroinflammation and cognitive deficits in P301S-Tau transgenic mouse model through inhibiting NF-κB activation. Quercetagitrin is a dual-target inhibitor of PTPN6 (IC50 = 1 μM) and PTPN9 (IC50 = 1.7 μM). Quercetagitrin enhances glucose uptake by mature C2C12 myoblasts. Quercetagitrin can be studied in research for Alzheimer’s disease and type 2 diabetes .
1
Dodecyl gallate
Dodecyl gallate
0 Images
1 Cited Publications
Cat. No.: HY-124082
CAS No.: 1166-52-5
Purity:  99.99%
Synonyms: Lauryl gallate
Target:  

Flavivirus Bacterial

Research Areas:  

Infection

Dodecyl gallate (Lauryl gallate) has been widely used as an antioxidant in food manufacturing, as well as in the pharmaceutical and cosmetic industries. Dodecyl gallate also acts antibacterial activity specifically against Gram-positive bacteria. Dodecyl gallate also is active against a highly relevant animal virus such as African swine fever virus (ASFV) .
1
Ancitabine hydrochloride
Ancitabine hydrochloride
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1 Cited Publications
Cat. No.: HY-N0093
CAS No.: 10212-25-6
Synonyms: Cyclocytidine hydrochloride; Cyclo-CMP hydrochloride; Cyclo-C
Category:  

Disease Research Fields Cancer

Target:  

Autophagy CMV DNA/RNA Synthesis Orthopoxvirus

Ancitabine (Cyclocytidine) hydrochloride is a cytarabine derivative that inhibits viral replication. Ancitabine hydrochloride blocks vaccinia virus DNA replication, the progression of viral protein synthesis from early to late stages, and one-step growth of vaccinia virus. Ancitabine hydrochloride is applicable to research related to vaccinia virus infection, leukemia, human cytomegalovirus infection and colorectal cancer .
9''-Methyl salvianolate B
9''-Methyl salvianolate B
0 Images
Cat. No.: HY-N2397
CAS No.: 1167424-31-8
Synonyms: MSB
Category:  

Simple Phenylpropanols Labiatae Samanea saman (Jacq.) Merr. Metabolic Disease Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields

Target:  

DNA/RNA Synthesis PPAR NF-κB Autophagy

9''-Methyl salvianolate B (MSB) is a blood-brain barrier-permeable inhibitor with high affinity for g5Rp, with a Kd value of 117 nM against African swine fever virus (ASFV) g5Rp. 9''-Methyl salvianolate B also acts as a ZBP1 inhibitor. It exhibits strong binding affinity to key proteins in the PPARγ/NF-κB pathway. 9''-Methyl salvianolate B blocks the interaction between ASFV g5Rp and host proteins eIF5A or RPS15. It restores hypusination modification of eIF5A, promotes autophagy (Autophagy), and inhibits ASFV replication. 9''-Methyl salvianolate B effectively disrupts ZBP1-mediated PANoptosome assembly. It effectively alleviates myocardial ischemia/reperfusion injury. 9''-Methyl salvianolate B can be used in studies related to African swine fever .
Thonningianin A
Thonningianin A
0 Images
Cat. No.: HY-N4084
CAS No.: 271579-11-4
Category:  

Thonningia sanguinea Phenols Polyphenols Plants Disease Research Fields Balanophoraceae Cancer

Target:  

Apoptosis

Thonningianin A, an ellagitannin, is isolated from the methanolic extract of the African medicinal herb, Thonningia sanguinea. The antioxidant properties of Th A involve radical scavenging, anti-superoxide formation and metal chelation. Anti-cancer activities .
Eicosatetraynoic acid
Eicosatetraynoic acid
0 Images
Cat. No.: HY-124108
CAS No.: 1191-85-1
Purity:  ≥99.0%
Synonyms: ETYA
Target:  

COX Lipoxygenase Orthopoxvirus Potassium Channel DNA/RNA Synthesis Drug Derivative

Research Areas:  

Infection Neurological Disease Inflammation/Immunology Cancer

Eicosatetraynoic acid (ETYA) is a non-metabolizable analog of Arachidonic acid (HY-109590) and also an inhibitor of the lipoxygenase (LOX)/cyclooxygenase (COX) pathway (ID50 = 8 μM and 4 μM). Eicosatetraynoic acid acts as a suicide substrate to inhibit the production of inflammatory mediators such as leukotrienes and prostaglandins. Eicosatetraynoic acid acts directly on cell membranes and membrane proteins to exert a wide range of effects, including blocking potassium channels, increasing cell membrane fluidity, elevating intracellular calcium levels, inhibiting DNA synthesis in tumor cells, inducing differentiation of certain cells, and specifically inhibiting the assembly and replication of orthopoxviruses. Eicosatetraynoic acid alleviates acute lung injury induced by chemicals such as phosgene .
Magainin 2
Magainin 2
0 Images
Cat. No.: HY-P0270
CAS No.: 108433-95-0
Synonyms: Magainin II
Category:  

Infection Natural Products Animals Disease Research Fields

Target:  

Bacterial Antibiotic Fungal

Magainin 2 (Magainin II) is an antimicrobial peptide (AMP) isolated from the skin of the African clawed frog Xenopus laevis. Magainin 2 displays antibiotic activity against numerous gram-negative and gram-positive bacteria. Magainin 2 also is active against protozoa . Magainin 2 exerts its cytotoxicity effects by preferential interactions with anionic phospholipids abundant in bacterial membranes .
Ebsulfur
Ebsulfur
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Cat. No.: HY-128170
CAS No.: 2527-03-9
Purity:  98.71%
Target:  

Parasite

Research Areas:  

Infection

Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase (TryR) of Trypanosoma brucei, with IC50 values of 61-293 nM for Trypanosoma brucei. Ebsulfur can be used for the research of African trypanosomiasis .
Harpagide
Harpagide
0 Images
Cat. No.: HY-N0397
CAS No.: 6926-08-5
Category:  

Iridoids Scrophularia ningpoensis Hemsl. Terpenoids Scrophulariaceae Plants Disease Research Fields Inflammation/Immunology

Target:  

Parasite

Harpagide is a class of iridoid glycoside isolated from Scrophularia ningpoensis and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (T.b. rhodesiense) with an IC50 of 21 μg/mL. Harpagide exerts significant antileishmanial activity against L. donovani with an IC50 value of 2.0 μg/mL. Harpagide also possess significant anti-inflammatory activities .
NMT-IN-1
NMT-IN-1
0 Images
Cat. No.: HY-153021
CAS No.: 326879-46-3
Purity:  ≥98.0%
Target:  

Parasite

Research Areas:  

Infection

NMT-IN-1 is a Trypanosoma brucei N-myristoyltransferase (TbNMT) inhibitor, with an IC50 of 31 μM against TbNMT and an IC50 of 66 μM against hNMT. As a thiazolidinone hit compound identified via virtual screening, NMT-IN-1 exerts enzymatic inhibitory effects by binding to the active site of TbNMT. NMT-IN-1 adopts a binding mode distinct from that of pyrazole sulfonamide inhibitors and can inhibit the myristoyl transfer reaction catalyzed by TbNMT. NMT-IN-1 is mainly used in the research of anti-parasitic lead compounds for human African trypanosomiasis (African sleeping sickness). It provides a structural basis for the subsequent optimization of TbNMT inhibitors with high activity, high selectivity and blood-brain barrier permeability .
Assay Types