526-55-6
526-55-6
Chemical Structure
Tryptophol
Synonym(s): Indole-3-ethanol
- CAS. Nr.: 526-55-6
- Formula:C10H11NO
- Molecular Weight:161.20
IUPAC Name: 2-(1H-indol-3-yl)ethan-1-ol
InChIKey: MBBOMCVGYCRMEA-UHFFFAOYSA-N
SMILES: OCCC1=CNC2=CC=CC=C12
Biological Activity: Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces apoptosis and cleavage of caspase-8. Tryptophol inhibits Cunninghamella blakesleeana biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy[1][2][3][4][5][6][7][8][9][10][11][12].
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Tryptophol | 99.80% | Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces apoptosis and cleavage of caspase-8. Tryptophol inhibits Cunninghamella blakesleeana biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy. | ||||||||||||||||||||
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Tryptophol (Standard) | 99.84% | Tryptophol (Standard) (Indole-3-ethanol (Standard)) is an analytical standard of Tryptophol (HY-W010155). This product is intended for use in research and analytical applications.Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces Apoptosis and cleavage of caspase-8. Tryptophol inhibits Cunninghamella blakesleeana biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy. | ||||||||||||||||||||
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Tryptophol-d4 | 99.97% | Tryptophol-d4 (Indole-3-ethanol-d4) is the deuterium labeled Tryptophol (HY-W010155). Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces apoptosis and cleavage of caspase-8. Tryptophol inhibits Cunninghamella blakesleeana biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy. | ||||||||||||||||||||
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References
- [1]. Zhao Z, et al. Tryptophol Improves the Biocontrol Efficacy of Scheffersomyces spartinae against the Gray Mold of Strawberries by Quorum Sensing. J Agric Food Chem. 2023 Dec 13;71(49):19739-19748. [Content Brief]
- [2]. Kosalec I, et al. Assessment of tryptophol genotoxicity in four cell lines in vitro: a pilot study with alkaline comet assay. Arh Hig Rada Toksikol. 2011 Mar;62(1):41-9. [Content Brief]
- [3]. Jin M, et al. The effect of tryptophol on the bacteriophage infection in high-temperature environment. Appl Microbiol Biotechnol. 2015 Oct;99(19):8101-11. [Content Brief]
- [4]. Kosalec I, et al. Genotoxicity of tryptophol in a battery of short-term assays on human white blood cells in vitro. Basic Clin Pharmacol Toxicol. 2008 May;102(5):443-52. [Content Brief]
- [5]. Inagaki S, et al. Tryptophol induces death receptor (DR) 5-mediated apoptosis in U937 cells. Biosci Biotechnol Biochem. 2007 Aug;71(8):2065-8. [Content Brief]
- [6]. Niwa T, et al. In Vitro Anti-inflammatory Activity of Tyrosol and Tryptophol: Metabolites of Yeast via the Ehrlich Pathway. Biol Pharm Bull. 2025;48(2):115-118. [Content Brief]
- [7]. Khan MF, et al. Regulation of Cunninghamella spp. biofilm growth by tryptophol and tyrosol. Biofilm. 2021 Mar 26;3:100046. [Content Brief]
- [8]. Seed JR, et al. The biological effects of tryptophol (indole-3-ethanol): hemolytic, biochemical and behavior modifying activity. Comp Biochem Physiol C Comp Pharmacol. 1978;60(2):175-85. [Content Brief]
- [9]. Feldstein A, et al. Tryptophol, 5-hydroxytryptophol and 5-methoxytryptophol induced sleep in mice. Life Sciences, 1970, 9(6): 323-329.
- [10]. FUKUMORI R, et al. Changes in seizure susceptibility after successive treatments of mice with tryptophol and ethanol. Journal of Pharmacy and Pharmacology, 1981, 33(1): 586-589.
- [11]. Satoh T, et al. Effect of tryptophol on pentylenetetrazol and picrotoxin induced convulsion in mice. Life Sci. 1979 May 28;24(22):2031-6. [Content Brief]
- [12]. Park I, et al. Gut Microbiota-Derived Indole-3-Carboxylate Influences Mucosal Integrity and Immunity Through the Activation of the Aryl Hydrocarbon Receptors and Nutrient Transporters in Broiler Chickens Challenged With Eimeria maxima. Front Immunol. 2022 Jun 23;13:867754. [Content Brief]
