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Cat. No.: HY-175974

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Antitrypanosomal agent 27

Antitrypanosomal agent 27 (Compound 5c) is a quinazoline compound with antitrypanosomal activity. Antitrypanosomal agent 27 inhibits T.b. brucei with a GI₅₀ of 31 nM. Antitrypanosomal agent 27 can be used for the research of human african trypanosomiasis.

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CAS No.: 2148927-96-0
화학식: C₂₆H₂₃F₃N₆O₂
분자량:508.50

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Antitrypanosomal agent 27 Chemical Structure

CAS No.: 2148927-96-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
Chemical Information
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Bioz

Biological Activity

제품 설명

All Parasite Isoforms :

In Vitro

Antitrypanosomal agent 27 shows the selectivity index ≥ 50 for human liver cancer HepG2 cells , and has no significant cytotoxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2148927-96-0
분자량 508.50
화학식 C₂₆H₂₃F₃N₆O₂
SMILES

CN1CCN(CC1)C2=CC=CC(C3=CC=C4N=CN=C(C4=C3)NC5=CC=C(C(C(F)(F)F)=C5)[N+]([O-])=O)=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Spijkers-Shaw S, et al. Optimization of Quinazolines for Inhibition of Trypanosoma brucei Proliferation. ACS Med Chem Lett. 2025 Aug 22;16(9):1806-1813. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- In Vitro
Chemical Information
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References

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Antitrypanosomal agent 27

All Parasite Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Antitrypanosomal agent 27 Related Classifications

HY-175974 Related Classifications