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Cat. No.: HY-124668

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CCR1 antagonist 12

CCR1 antagonist 12 (Compound 12) is an antagonist for CCR1 with IC₅₀ of 3 nM for human CCR1. CCR1 antagonist 12 inhibits CCL3-induced transwell chemotaxis with an IC₅₀ of 0.009 µM. CCR1 antagonist 12 exhibits good pharmacokinetic characters in rats model.

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CAS No.: 921208-19-7
화학식: C₂₅H₂₇ClFN₃O₄
분자량:487.95

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

CCR1 antagonist 12 Chemical Structure

CAS No.: 921208-19-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

CCR1

3 nM (IC₅₀)

All CCR Isoforms :

Chemical Information

CAS No. 921208-19-7
분자량 487.95
화학식 C₂₅H₂₇ClFN₃O₄
SMILES

CC(NC1=CC(Cl)=C(OC)C=C1/C=C/C(N2CC3COCC(N3CC4=CC=C(F)C=C4)C2)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Revesz L, et al. Bridged piperazines and piperidines as CCR1 antagonists with oral activity in models of arthritis and multiple sclerosis[J]. Letters in Drug Design & Discovery, 2006, 3(10): 689-694.

Calculators

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Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
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CCR1 antagonist 12

All CCR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CCR1 antagonist 12 Related Classifications

HY-124668 Related Classifications