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Cat. No.: HY-137697A

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ddCTP tetrasodium

ddCTP tetrasodium is a type of chain-terminating deoxynucleotide. ddCTP tetrasodium can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP tetrasodium can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP tetrasodium is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication.

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화학식: C₉H₁₂N₃Na₄O₁₂P₃
분자량:539.08

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

ddCTP tetrasodium Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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Biological Activity

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IC₅₀ & Target

DNA Polymerase

All HIV Isoforms :

All DNA/RNA Synthesis Isoforms :

In Vitro

ddCTP (0.1 mM; 20 min) tetrasodium enables discrimination of nearly identical RNA sequences via chain termination during poisoned primer extension reactions using total cellular RNA or purified in vitro transcripts, generating extension products of distinct sizes detectable by gel electrophoresis^[1].
ddCTP tetrasodium, in addition to inhibiting viral reverse transcriptase, may also inhibit DNA polymerase γ in mammalian cells. This enzyme is responsible for mitochondrial DNA synthesis. Inhibition of DNA polymerase γ leads to decreased mitochondrial DNA content and impaired function^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 539.08
화학식 C₉H₁₂N₃Na₄O₁₂P₃
SMILES

O=[P](O[P](O[P](O[Na])(O[Na])=O)(O[Na])=O)(O[Na])OC[C@@H]1CC[C@H](N2C(N=C(N)C=C2)=O)O1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Nilsen TW. Poisoned primer extension. Cold Spring Harb Protoc. 2015 Jan 5;2015(1):pdb.prot080986.
[Content Brief]

[2]. Adkins JC, et al. An update of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in the management of HIV infection. Drugs. 1997 Jun;53(6):1054-80.

[3]. Z G Chidgeavadze, et al. 3'-Fluoro-2',3'-dideoxyribonucleoside 5'-triphosphates: terminators of DNA synthesis. FEBS Lett. 1985 Apr 22;183(2):275-8.
[Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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ddCTP tetrasodium

All HIV Isoforms

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

ddCTP tetrasodium Related Classifications

HY-137697A Related Classifications