Koshidacin B
Koshidacin B is an antiplasmodial cyclic tetrapeptide with antiplasmodial activity against P. falciparum FCR3 and K1 strain with IC50 values of 0.89 and 0.83 μM, respectively. Koshidacin B suppresses malaria parasites in vivo, it can be used for the research of parasites infection.
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- CAS No.: 2925302-01-6
- 화학식: C28H40N4O7
- 분자량:544.64
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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Biological Activity
IC50: 0.89 μM (P. falciparum FCR3 strain), 0.83 μM (P. falciparum K1 strain), 14.7 μM (human MRC-5 cells)[1]
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Cell Line
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Type | Value | Description | References |
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| MRC5 | CC50 |
14.7 μM
Compound: 2
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Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 24 hrs by MTT assay
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[PMID: 36282784] |
Koshidacin B (72 h) shows antiplasmodial activity against chloroquine-sensitive P. falciparum FCR3 strain and chloroquine-resistant P. falciparum K1 strain with IC50 values of 0.89 and 0.83 μM, respectively[1]. Koshidacin B (7 d) shows cytotoxicity against human MRC-5 cells with an IC50 value of 14.7 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:P. berghei N strain-infected ICR (CD1) mice[1]
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Dosage:30 mg/kg
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Administration:Intraperitoneal injection; 30 mg/kg; once daily; for 4 days
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Result:Suppressed 41% of malaria parasites.
Chemical Information
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CAS No. 2925302-01-6
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분자량 544.64
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화학식 C28H40N4O7
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SMILES
OC[C@H](O)C(CCCCC[C@H](NC([C@H]1CCCN1C([C@@H](NC(C(C)(C)N2)=O)CC3=CC=CC=C3)=O)=O)C2=O)=O
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Structure Classification
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Initial Source
Pochonia boninensis
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Koshidacin B Related Classifications
HY-N10624 Related Classifications
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