country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-176234

Copy Link Print Information

PDE4-IN-28

PDE4-IN-28 (Compound G1) is a PDE4D inhibitor (IC₅₀: 29 nM). PDE4-IN-28 inhibits the production of TNF-α and NO (IC₅₀: 13.32 and 2.32 μM, respectively). PDE4-IN-28 exhibits anti-inflammatory, antibacterial and analgesic effects in a rat pressure ulcer (PU) model and promotes HUVEC cell migration, thereby accelerating wound healing.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₈H₂₇F₂N₉O₆
분자량:623.57

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

PDE4-IN-28 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Parmacokinetics
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

PDE4D

29 nM (IC₅₀)

All Phosphodiesterase (PDE) Isoforms :

All TNF Receptor Isoforms :

All NO Synthase Isoforms :

Parmacokinetics

Species	Dose	Route	AUC_0-t	AUC_0-∞	C_max	T_1/2	T_max	F	C₀	V_z	CL
Rat^[1]	10 mg/kg	p.o.	0.0256 μg·h/mL	0.0268 μg·h/mL	14.4 ng/mL	1.4 h	0.25 h	5.5 %	/	/	/
Rat^[1]	5 mg/kg	i.v.	0.235 μg·h/mL	0.236 μg·h/mL	/	0.28 h	/	/	1141 ng/mL	8.757 L/kg	21486 mL/h/kg

Chemical Information

분자량 623.57
화학식 C₂₈H₂₇F₂N₉O₆
SMILES

O=C1N(C2=C(C(N1C)=O)N(CCC(NNC(C3=NN4C(C5=CC(OCC6CC6)=C(C=C5)OC(F)F)=CC=NC4=C3)=O)=O)C=N2)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Qian X, et al. Design, Synthesis, and Biological Evaluation of New PDE4 Inhibitors for the Treatment of Pressure Ulcers. J Med Chem. 2025 Jun 12;68(11):11628-11647. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

견적 받기 해외재고보유

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

PDE4-IN-28

All Phosphodiesterase (PDE) Isoforms

All TNF Receptor Isoforms

All NO Synthase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

PDE4-IN-28 Related Classifications

HY-176234 Related Classifications