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Cat. No.: HY-150081

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PRMT5-IN-21

PRMT5-IN-21 (compound 1) is a potent cyclonucleoside PRMT5 inhibitor.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2922673-38-7
화학식: C₁₈H₁₈F₂N₆O₃
분자량:404.37

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

PRMT5-IN-21 Chemical Structure

CAS No.: 2922673-38-7

사이즈

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재고

수량

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

PRMT5-IN-21 (compound 1) is a potent cyclonucleoside PRMT5 inhibitor^[1].

IC₅₀ & Target

PRMT5

All Histone Methyltransferase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Sf21	IC₅₀	5.7 μM Compound: 1	Inhibition of full-length (FL)-PRMT5:MEP50 enzyme complex (unknown origin) expressed in Sf21 cells assessed as reduction in methylation activity using the N-terminus of H4 histone derived substrate peptide H4R3(Me1) by PRMT5:MEP50 biochemical assay Inhibition of full-length (FL)-PRMT5:MEP50 enzyme complex (unknown origin) expressed in Sf21 cells assessed as reduction in methylation activity using the N-terminus of H4 histone derived substrate peptide H4R3(Me1) by PRMT5:MEP50 biochemical assay	[PMID: 35594650]

Chemical Information

CAS No. 2922673-38-7
분자량 404.37
화학식 C₁₈H₁₈F₂N₆O₃
SMILES

FC1=C(F)C=CC([C@@H]2[C@@H]3[C@@H](O)[C@@H](O)[C@H](N4C(N=CN=C5N)=C5N=C4NCC2)O3)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kawamura S, et al. Design and synthesis of unprecedented 9- and 10-membered cyclonucleosides with PRMT5 inhibitory activity. Bioorg Med Chem. 2022 Jul 15;66:116820. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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수량:
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PRMT5-IN-21

All Histone Methyltransferase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

PRMT5-IN-21 Related Classifications

HY-150081 Related Classifications