country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-W794785

Copy Link Print Information

WAY 208466

WAY 208466 is a selective 5-HT6 receptor agonist with an EC₅₀ of 7.3 nM. WAY-208466 increases GABA levels following both acute and chronic administration in the dorsolateral frontal cortex of rat models with stereotaxic surgery. WAY 208466 can be used for anxiety-related disorders like obsessive compulsive disorder (OCD) research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 633304-27-5
화학식: C₁₇H₁₈FN₃O₂S
분자량:347.41

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

WAY 208466 Chemical Structure

CAS No.: 633304-27-5

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

5-HT₆ Receptor

7.3 nM (EC₅₀)

5-HT₇ Receptor

4764 nM (EC₅₀)

5-HT_2A Receptor

351 nM (EC₅₀)

5-HT_2B Receptor

313 nM (EC₅₀)

5-HT_2C (Ant) Rceptor

217 nM (EC₅₀)

5-HT_2C (Ago) Receptor

644 nM (EC₅₀)

All 5-HT Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	351 nM Compound: 10e, WAY-208466	Displacement of [125I]DOI from human cloned 5HT2A receptor expressed in CHO cells Displacement of [125I]DOI from human cloned 5HT2A receptor expressed in CHO cells	[PMID: 19523834]
CHO	IC₅₀	4764 nM Compound: 10e, WAY-208466	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	[PMID: 19523834]
CHO	IC₅₀	644 nM Compound: 10e, WAY-208466	Displacement of [3H]5-HT from human cloned 5HT2C receptor expressed in CHO cells Displacement of [3H]5-HT from human cloned 5HT2C receptor expressed in CHO cells	[PMID: 19523834]
CHO-K1	IC₅₀	>5000 nM Compound: 10e, WAY-208466	Displacement of [3H]spiperone from human cloned dopamine D4 receptor expressed in CHO-K1 cells Displacement of [3H]spiperone from human cloned dopamine D4 receptor expressed in CHO-K1 cells	[PMID: 19523834]
CHO-K1	IC₅₀	<5000 nM Compound: 10e, WAY-208466	Displacement of [3H]spiperone from human cloned dopamine D2 receptor expressed in CHO-K1 cells Displacement of [3H]spiperone from human cloned dopamine D2 receptor expressed in CHO-K1 cells	[PMID: 19523834]
CHO-K1	IC₅₀	>5000 nM Compound: 10e, WAY-208466	Displacement of [3H]spiperone from human cloned dopamine D3 receptor expressed in CHO-K1 cells Displacement of [3H]spiperone from human cloned dopamine D3 receptor expressed in CHO-K1 cells	[PMID: 19523834]
HeLa	EC₅₀	7.3 nM Compound: 10e, WAY-208466	Agonist activity at human cloned 5HT6 receptor expressed in HeLa cells assessed as induction of adenylyl cyclase activity by RIA Agonist activity at human cloned 5HT6 receptor expressed in HeLa cells assessed as induction of adenylyl cyclase activity by RIA	[PMID: 19523834]
HeLa	EC₅₀	7.3 nM Compound: 3b	Agonist activity at human HT6 receptor expressed in human HeLa cells assessed as intracellular cAMP level by radioimmunoassay Agonist activity at human HT6 receptor expressed in human HeLa cells assessed as intracellular cAMP level by radioimmunoassay	[PMID: 19884004]
HeLa	EC₅₀	7.3 nM Compound: 20, WAY-208466	Agonist activity at human 5-HT6 receptor expressed in HeLa cells after 10 mins by scintillation proximity assay Agonist activity at human 5-HT6 receptor expressed in HeLa cells after 10 mins by scintillation proximity assay	[PMID: 26099069]

Chemical Information

CAS No. 633304-27-5
분자량 347.41
화학식 C₁₇H₁₈FN₃O₂S
SMILES

O=S(C1=CC(F)=CC=C1)(C2=CN(CCN(C)C)C3=C2C=CC=N3)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Schechter LE, et al. Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33(6):1323-35. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

WAY 208466

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

WAY 208466 Related Classifications

HY-W794785 Related Classifications