1. GPCR/G Protein
  2. Adenosine Receptor
  3. LUF6096

LUF6096 

Cat. No.: HY-10915
Handling Instructions

LUF6096, a potent allosteric enhancer of the adenosine A3 receptor, is able to allosterically enhance agonist binding. LUF6096 shows low orthosteric affinity for any of the adenosine receptors. LUF6096 shows protective effects in myocardial ischemia/reperfusion injury.

For research use only. We do not sell to patients.

LUF6096 Chemical Structure

LUF6096 Chemical Structure

CAS No. : 1116652-18-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 330 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 330 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 480 In-stock
Estimated Time of Arrival: December 31
25 mg USD 950 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

LUF6096, a potent allosteric enhancer of the adenosine A3 receptor, is able to allosterically enhance agonist binding. LUF6096 shows low orthosteric affinity for any of the adenosine receptors. LUF6096 shows protective effects in myocardial ischemia/reperfusion injury[1][2].

IC50 & Target

adenosine A3 receptor[1]

In Vitro

LUF6096 (10 μM; 30-120 min) decreases the dissociation rate of 125I-AB-MECA from the A3 receptor by 2.5 times in CHO cell membranes[1].
LUF6096 (10 μM; pretreated for 15 min) significantly and dramatically enhances the intrinsic activity of Cl-IB-MECA for the inhibition of the forskolin-stimulated cAMP production in CHO cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LUF6096 (twice i.v. bolus for 0.5 mg/kg or single i.v. bolus for 1 mg/kg) protects against myocardial ischemia/reperfusion injury in dogs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult mongrel dogs (15-25 kg) were subjected left anterior descending (LAD) coronary artery occlusion and reperfusion[1]
Dosage: Twice i.v. bolus for 0.5 mg/kg or single i.v. bolus for 1 mg/kg
Administration: I.v. bolus
Result: Produced a marked reduction in infarct size (∼50% reduction) compared with vehicle-treated dogs.
Molecular Weight

414.33

Formula

C₂₂H₂₁Cl₂N₃O

CAS No.
SMILES

O=C(NC1=CC(NC2=CC=C(Cl)C(Cl)=C2)=NC3=CC=CC=C31)C4CCCCC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (48.27 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4135 mL 12.0677 mL 24.1354 mL
5 mM 0.4827 mL 2.4135 mL 4.8271 mL
10 mM 0.2414 mL 1.2068 mL 2.4135 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2 mg/mL (4.83 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

LUF6096LUF 6096LUF-6096Adenosine ReceptorP1 receptorallostericenhanceradenosineA3myocardialischemiareperfusionInhibitorinhibitorinhibit

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Product Name:
LUF6096
Cat. No.:
HY-10915
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