1. GPCR/G Protein
  2. Adenosine Receptor

Tozadenant (Synonyms: SYN115)

Cat. No.: HY-10995 Purity: 98.06%
Handling Instructions

Tozadenant is an adenosine A2A receptor antagonist, with Ki of 11.5 nM on human A2A and 6 nM on rhesus A2A.

For research use only. We do not sell to patients.

Tozadenant Chemical Structure

Tozadenant Chemical Structure

CAS No. : 870070-55-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 158 In-stock
Estimated Time of Arrival: December 31
5 mg USD 144 In-stock
Estimated Time of Arrival: December 31
10 mg USD 216 In-stock
Estimated Time of Arrival: December 31
50 mg USD 648 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1152 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Top Publications Citing Use of Products

    Tozadenant purchased from MCE. Usage Cited in: PLoS One. 2016 Nov 11;11(11):e0166415.

    The endogenous Aβ production of SH-SY5Y cells upon the treatment with 0.1% of DMSO (Vehicle), Istradefylline (Istrad.), Preladenant (Prelad.) or Tozadenant (Tozad.) at 30 nM for 24 h is examined.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Tozadenant is an adenosine A2A receptor antagonist, with Ki of 11.5 nM on human A2A and 6 nM on rhesus A2A.

    IC50 & Target

    Ki: 6 nM (Rhesus A2A), 11.5 nM (Human A2A)

    In Vivo

    18F-MNI-444 regional uptake is consistent with A2A receptor distribution in the brain. Selectivity is demonstrated by dose-dependent blocking by tozadenant (1.5, 10.5 mg/kg) and preladenant[1].

    Clinical Trial
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (123.00 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4600 mL 12.3001 mL 24.6002 mL
    5 mM 0.4920 mL 2.4600 mL 4.9200 mL
    10 mM 0.2460 mL 1.2300 mL 2.4600 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (6.15 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (6.15 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (6.15 mM); Clear solution

    References
    Molecular Weight

    406.50

    Formula

    C₁₉H₂₆N₄O₄S

    CAS No.

    870070-55-6

    SMILES

    O=C(NC1=NC2=C(C=CC(N3CCOCC3)=C2S1)OC)N4CCC(O)(CC4)C

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    • Molarity Calculator

    • Dilution Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
    C1   V1   C2   V2

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    Inquiry Information

    Product Name:
    Tozadenant
    Cat. No.:
    HY-10995
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    Tozadenant

    Cat. No.: HY-10995