1116652-18-6
1116652-18-6
Chemical Structure
LUF6096
- CAS No.: 1116652-18-6
- Formula:C22H21Cl2N3O
- Molecular Weight:414.33
IUPAC Name: N-(2-((3,4-dichlorophenyl)amino)quinolin-4-yl)cyclohexanecarboxamide
InChIKey: UWEIQVQNNLVOEI-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(NC2=CC=C(Cl)C(Cl)=C2)=NC3=CC=CC=C31)C4CCCCC4
Biological Activity: LUF6096, a potent allosteric enhancer of the adenosine A3 receptor, is able to allosterically enhance agonist binding. LUF6096 shows low orthosteric affinity for any of the adenosine receptors. LUF6096 shows protective effects in myocardial ischemia/reperfusion injury[1][2].
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LUF6096 | 99.16% | LUF6096, a potent allosteric enhancer of the adenosine A3 receptor, is able to allosterically enhance agonist binding. LUF6096 shows low orthosteric affinity for any of the adenosine receptors. LUF6096 shows protective effects in myocardial ischemia/reperfusion injury. | ||||||||||||||||||||
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LUF6096 (Standard) | ≥98% | LUF6096 (Standard) is the analytical standard of LUF6096 (HY-10915). This product is intended for research and analytical applications. LUF6096, a potent allosteric enhancer of the adenosine A3 receptor, is able to allosterically enhance agonist binding. LUF6096 shows low orthosteric affinity for any of the adenosine receptors. LUF6096 shows protective effects in myocardial ischemia/reperfusion injury. | ||||||||||||||||||||
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References
- [1]. Heitman LH, et, al. A series of 2,4-disubstituted quinolines as a new class of allosteric enhancers of the adenosine A3 receptor. J Med Chem. 2009 Feb 26;52(4):926-31. [Content Brief]
- [2]. Du L, et, al. Protection from myocardial ischemia/reperfusion injury by a positive allosteric modulator of the A₃ adenosine receptor. J Pharmacol Exp Ther. 2012 Jan;340(1):210-7. [Content Brief]
Keywords
